A case of methotrexate‐associated Epstein‐Barr virus‐positive mucocutaneous ulcer

Epstein‐Barr virus‐positive mucocutaneous ulcer (EBVMCU) is a B‐cell proliferative disorder that has been designated as a provisional entity in the 2017 World Health Organization classification for lymphoid neoplasms. While EBVMCU may contain varying numbers of cells with Hodgkin and Reed‐Sternberg...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Skin Health and Disease Ročník 2; číslo 2; s. e108 - n/a
Hlavní autoři: Sakamoto, Keiko, Baba, Takeshi, Takatori, Hiroaki, Nagao, Keisuke, Misawa, Junko, Honda, Tetsuya
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley 01.06.2022
Oxford University Press
John Wiley and Sons Inc
Témata:
Antigens
Bacterial infections
Biopsy
Case Report
Case Reports
Conflicts of interest
Dermatology
Editing
Epstein-Barr virus
Histology
Lymphocytes
Lymphoma
Rheumatoid arthritis
RL1-803
Supervision
Ulcers
Writing
ISSN:2690-442X, 2690-442X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Epstein‐Barr virus‐positive mucocutaneous ulcer (EBVMCU) is a B‐cell proliferative disorder that has been designated as a provisional entity in the 2017 World Health Organization classification for lymphoid neoplasms. While EBVMCU may contain varying numbers of cells with Hodgkin and Reed‐Sternberg cells‐like morphology, the clinical course is benign and must be distinguished from lymphomas. Patients who develop EBVMCU are commonly immunocompromised, with methotrexate (MTX) as the leading cause. Most previously reported cases of EBVMCU describe mucosal ulcers with very little documentation on skin lesions and its course. Here, we report a case of MTX‐associated EBVMCU of the lower leg that underwent spontaneous regression after MTX withdrawal, during which negative conversion of local Epstein‐Barr virus activation was confirmed.
Bibliografie:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Report-1
ObjectType-Feature-4
content type line 23
ObjectType-Article-3
ISSN:2690-442X
2690-442X
DOI:10.1002/ski2.108