Protease‐activated receptor‐1 contributes to renal injury and interstitial fibrosis during chronic obstructive nephropathy

End‐stage renal disease, the final stage of all chronic kidney disorders, is associated with renal fibrosis and inevitably leads to renal failure and death. Transition of tubular epithelial cells (TECs) into mesenchymal fibroblasts constitutes a proposed mechanism underlying the progression of renal...

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Vydáno v:	Journal of cellular and molecular medicine Ročník 23; číslo 2; s. 1268 - 1279
Hlavní autoři:	Waasdorp, Maaike, de Rooij, Dennis M., Florquin, Sandrine, Duitman, JanWillem, Spek, C. Arnold
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England John Wiley & Sons, Inc 01.02.2019 John Wiley and Sons Inc
Témata:	Acute Kidney Injury - etiology Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Chronic Disease Epithelial cells Epithelial-Mesenchymal Transition epithelial‐to‐mesenchymal transition Fibroblasts Fibrosis Fibrosis - etiology Fibrosis - metabolism Fibrosis - pathology Kidney Diseases - physiopathology Macrophages Mesenchyme Mice Mice, Inbred C57BL Mice, Knockout Nephritis, Interstitial - etiology Nephritis, Interstitial - metabolism Nephritis, Interstitial - pathology Nephropathy obstructive nephropathy Original protease‐activated receptor‐1 Proteinase Receptor, PAR-1 - physiology Renal failure renal fibrosis Rodents Signal Transduction Transforming Growth Factor beta1 - metabolism unilateral ureter obstruction Ureter Ureteral Obstruction - complications United States > US Netherlands protease-activated receptor-1 renal fibrosis unilateral ureter obstruction obstructive nephropathy epithelial-to-mesenchymal transition
ISSN:	1582-1838, 1582-4934, 1582-4934
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