Critical assessment of methods of protein structure prediction (CASP)—Round XIV

Critical assessment of structure prediction (CASP) is a community experiment to advance methods of computing three‐dimensional protein structure from amino acid sequence. Core components are rigorous blind testing of methods and evaluation of the results by independent assessors. In the most recent...

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Podrobná bibliografia
Vydané v:	Proteins, structure, function, and bioinformatics Ročník 89; číslo 12; s. 1607 - 1617
Hlavní autori:	Kryshtafovych, Andriy, Schwede, Torsten, Topf, Maya, Fidelis, Krzysztof, Moult, John
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Hoboken, USA John Wiley & Sons, Inc 01.12.2021 Wiley Subscription Services, Inc
Predmet:	Alphafold Amino Acid Sequence Amino acids CASP community wide experiment Computational Biology Crystal structure Deep learning Model accuracy Models, Statistical Molecular Dynamics Simulation Predictions Protein Conformation Protein Folding Protein structure protein structure prediction Proteins Proteins - chemistry Proteins - metabolism Sequence Analysis, Protein Software Alphafold community wide experiment protein folding CASP protein structure prediction
ISSN:	0887-3585, 1097-0134, 1097-0134
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Popis
Shrnutí:	Critical assessment of structure prediction (CASP) is a community experiment to advance methods of computing three‐dimensional protein structure from amino acid sequence. Core components are rigorous blind testing of methods and evaluation of the results by independent assessors. In the most recent experiment (CASP14), deep‐learning methods from one research group consistently delivered computed structures rivaling the corresponding experimental ones in accuracy. In this sense, the results represent a solution to the classical protein‐folding problem, at least for single proteins. The models have already been shown to be capable of providing solutions for problematic crystal structures, and there are broad implications for the rest of structural biology. Other research groups also substantially improved performance. Here, we describe these results and outline some of the many implications. Other related areas of CASP, including modeling of protein complexes, structure refinement, estimation of model accuracy, and prediction of inter‐residue contacts and distances, are also described.
Bibliografia:	Funding information National Institute of General Medical Sciences, Grant/Award Number: R01GM100482 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0887-3585 1097-0134 1097-0134
DOI:	10.1002/prot.26237