Preconditioning influences mesenchymal stem cell properties in vitro and in vivo

Various diseases and toxic factors easily impair cellular and organic functions in mammals. Organ transplantation is used to rescue organ function, but is limited by scarce resources. Mesenchymal stem cell (MSC)‐based therapy carries promising potential in regenerative medicine because of the self‐r...

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Vydáno v:Journal of cellular and molecular medicine Ročník 22; číslo 3; s. 1428 - 1442
Hlavní autoři: Hu, Chenxia, Li, Lanjuan
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.03.2018
John Wiley and Sons Inc
Témata:
Animals
Antioxidants - pharmacology
Cell culture
Cell Culture Techniques
Cell Hypoxia
Cell self-renewal
Cytokines - pharmacology
Electromagnetic Fields
Humans
Immunologic Factors - pharmacology
Intercellular Signaling Peptides and Proteins - pharmacology
in vitro
in vivo
Ischemic Preconditioning - methods
mesenchymal stem cell
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - drug effects
Mesenchymal Stem Cells - immunology
Mesenchyme
preconditioning
Regenerative medicine
Regenerative Medicine - methods
Review
Reviews
Small Molecule Libraries - pharmacology
Stem cells
stemness
Tissue engineering
Tissue Engineering - methods
Transplantation
Vitamins - pharmacology
mesenchymal stem cell
in vitro
in vivo
stemness
preconditioning
ISSN:1582-1838, 1582-4934, 1582-4934
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Shrnutí:Various diseases and toxic factors easily impair cellular and organic functions in mammals. Organ transplantation is used to rescue organ function, but is limited by scarce resources. Mesenchymal stem cell (MSC)‐based therapy carries promising potential in regenerative medicine because of the self‐renewal and multilineage potency of MSCs; however, MSCs may lose biological functions after isolation and cultivation for a long time in vitro. Moreover, after they are injected in vivo and migrate into the damaged tissues or organs, they encounter a harsh environment coupled with death signals due to the inadequate tensegrity structure between the cells and matrix. Preconditioning, genetic modification and optimization of MSC culture conditions are key strategies to improve MSC functions in vitro and in vivo, and all of these procedures will contribute to improving MSC transplantation efficacy in tissue engineering and regenerative medicine. Preconditioning with various physical, chemical and biological factors is possible to preserve the stemness of MSCs for further application in studies and clinical tests. In this review, we mainly focus on preconditioning and the corresponding mechanisms for improving MSC activities in vitro and in vivo; we provide a glimpse into the promotion of MSC‐based cell therapy development for regenerative medicine. As a promising consequence, MSC transplantation can be applied for the treatment of some terminal diseases and can prolong the survival time of patients in the near future.
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ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.13492