Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria

Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis and aquaporin-4-seropositive neuromyelitis optica spectrum disorder. Based on an extensive literature review and a str...

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Veröffentlicht in:Lancet neurology Jg. 22; H. 3; S. 268 - 282
Hauptverfasser: Banwell, Brenda, Bennett, Jeffrey L, Marignier, Romain, Kim, Ho Jin, Brilot, Fabienne, Flanagan, Eoin P, Ramanathan, Sudarshini, Waters, Patrick, Tenembaum, Silvia, Graves, Jennifer S, Chitnis, Tanuja, Brandt, Alexander U, Hemingway, Cheryl, Neuteboom, Rinze, Pandit, Lekha, Reindl, Markus, Saiz, Albert, Sato, Douglas Kazutoshi, Rostasy, Kevin, Paul, Friedemann, Pittock, Sean J, Fujihara, Kazuo, Palace, Jacqueline
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.03.2023
Elsevier Limited
Schlagworte:
Adults
Antibodies
Aquaporin 4
Autoantibodies
Brain stem
Cerebellum
Clinical trials
Demyelination
Encephalitis
Encephalomyelitis
Glycoproteins
Humans
Immunoglobulin G
Inflammatory diseases
Literature reviews
Medical diagnosis
Medical research
Multiple sclerosis
Multiple Sclerosis - diagnosis
Myelin
Myelin-Oligodendrocyte Glycoprotein
Myelitis
Neuritis
Neuromyelitis
Neuromyelitis Optica
Oligodendrocyte-myelin glycoprotein
Optic nerve
Optic Neuritis
Pediatrics
Spinal cord
Steroids
Visual acuity
ISSN:1474-4422, 1474-4465, 1474-4465
Online-Zugang:Volltext
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Zusammenfassung:Serum antibodies directed against myelin oligodendrocyte glycoprotein (MOG) are found in patients with acquired CNS demyelinating syndromes that are distinct from multiple sclerosis and aquaporin-4-seropositive neuromyelitis optica spectrum disorder. Based on an extensive literature review and a structured consensus process, we propose diagnostic criteria for MOG antibody-associated disease (MOGAD) in which the presence of MOG-IgG is a core criterion. According to our proposed criteria, MOGAD is typically associated with acute disseminated encephalomyelitis, optic neuritis, or transverse myelitis, and is less commonly associated with cerebral cortical encephalitis, brainstem presentations, or cerebellar presentations. MOGAD can present as either a monophasic or relapsing disease course, and MOG-IgG cell-based assays are important for diagnostic accuracy. Diagnoses such as multiple sclerosis need to be excluded, but not all patients with multiple sclerosis should undergo screening for MOG-IgG. These proposed diagnostic criteria require validation but have the potential to improve identification of individuals with MOGAD, which is essential to define long-term clinical outcomes, refine inclusion criteria for clinical trials, and identify predictors of a relapsing versus a monophasic disease course.
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ISSN:1474-4422
1474-4465
1474-4465
DOI:10.1016/S1474-4422(22)00431-8