Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB

The Origin Recognition Complex (ORC) is a six-subunit protein important for the initiation of DNA replication in eukaryotic cells. Orc6 is the smallest and the least conserved among ORC subunits. It is required for the DNA replication but also has a function in cytokinesis in metazoan species, howev...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 18; p. 7373
Main Authors:	Liu, Shixuan, Balasov, Maxim, Wang, Hongfei, Wu, Lijie, Chesnokov, Igor N, Liu, Yingfang
Format:	Journal Article
Language:	English
Published:	United States 03.05.2011
Subjects:	Amino Acid Sequence Animals Bromodeoxyuridine Chromatography, Gel Cloning, Molecular Crystallization DNA Replication - genetics Drosophila Electrophoresis, Polyacrylamide Gel Green Fluorescent Proteins Humans Models, Molecular Molecular Sequence Data Origin Recognition Complex - chemistry Origin Recognition Complex - genetics Protein Binding Protein Conformation Sequence Alignment Sequence Homology Transcription Factor TFIIB - genetics Xenopus
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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