Autopsy findings in COVID-19-related deaths: a literature review

Although many clinical reports have been published, little is known about the pathological post-mortem findings from people who have died of the novel coronavirus disease. The need for postmortem information is urgent to improve patient management of mild and severe illness, and treatment strategies...

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Vydané v:	Forensic science, medicine, and pathology Ročník 17; číslo 2; s. 279 - 296
Hlavní autori:	Maiese, Aniello, Manetti, Alice Chiara, La Russa, Raffaele, Di Paolo, Marco, Turillazzi, Emanuela, Frati, Paola, Fineschi, Vittorio
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Springer US 01.06.2021 Springer
Predmet:	Alveolar Epithelial Cells - pathology Autopsy Brain - pathology Coronaviruses COVID-19 - pathology Criminology and Criminal Justice Database searching Fibrin - metabolism Fibroblasts - pathology Forensic Medicine Humans Internet/Web search services Kidney - pathology Leukocytes, Mononuclear - pathology Lung - pathology Medicine Medicine & Public Health Myositis - pathology Online searching Pathology Respiratory Mucosa - pathology Review Thrombosis - pathology COVID-19 Findings Pathophysiology Autopsy
ISSN:	1547-769X, 1556-2891, 1556-2891
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Popis
Shrnutí:	Although many clinical reports have been published, little is known about the pathological post-mortem findings from people who have died of the novel coronavirus disease. The need for postmortem information is urgent to improve patient management of mild and severe illness, and treatment strategies. The present systematic review was carried out according to the Preferred Reporting Items for Systematic Review (PRISMA) standards. A systematic literature search and a critical review of the collected studies were conducted. An electronic search of PubMed, Science Direct Scopus, Google Scholar, and Excerpta Medica Database (EMBASE) from database inception to June 2020 was performed. We found 28 scientific papers; the total amount of cases is 341. The major histological feature in the lung is diffuse alveolar damage with hyaline membrane formation, alongside microthrombi in small pulmonary vessels. It appears that there is a high incidence of deep vein thrombosis and pulmonary embolism among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed. A uniform COVID-19 post-mortem diagnostic protocol has not yet been developed. In a time in which international collaboration is essential, standardized diagnostic criteria are fundamental requirements.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3
ISSN:	1547-769X 1556-2891 1556-2891
DOI:	10.1007/s12024-020-00310-8