Safety and efficacy of phage therapy in difficult-to-treat infections: a systematic review

According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial infections is increasing worldwide, resulting in increased morbidity and mortality and a rising pressure on health-care systems. However, the development of new antibiotics is an expensive and time-consuming pr...

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Vydané v:The Lancet infectious diseases Ročník 22; číslo 8; s. e208 - e220
Hlavní autori: Uyttebroek, Saartje, Chen, Baixing, Onsea, Jolien, Ruythooren, Fred, Debaveye, Yves, Devolder, David, Spriet, Isabel, Depypere, Melissa, Wagemans, Jeroen, Lavigne, Rob, Pirnay, Jean-Paul, Merabishvili, Maya, De Munter, Paul, Peetermans, Willy E, Dupont, Lieven, Van Gerven, Laura, Metsemakers, Willem-Jan
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Ltd 01.08.2022
Elsevier Limited
Predmet:
Anti-Bacterial Agents - therapeutic use
Antibiotic resistance
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial infections
Bacterial Infections - drug therapy
Bacteriophages
Bias
Case studies
Citation management software
Clinical medicine
Clinical trials
Cystic fibrosis
Data collection
Drug resistance
Exports
Humans
Infectious diseases
Intervention
Morbidity
Pathogens
Patients
Phage Therapy - methods
Phages
Pulmonology
Safety
Staphylococcus infections
Systematic review
Therapy
ISSN:1473-3099, 1474-4457, 1474-4457
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Shrnutí:According to the latest reports from WHO, the incidence of antibiotic-resistant bacterial infections is increasing worldwide, resulting in increased morbidity and mortality and a rising pressure on health-care systems. However, the development of new antibiotics is an expensive and time-consuming process, urging scientists to seek alternative antimicrobial strategies. Over the past few decades, the concept of therapeutic administration of bacteriophages (also known as phages) has gained popularity worldwide. Although conceptually promising, the widespread implementation of phage therapy in routine clinical practice is restricted by the scarcity of safety and efficacy data obtained according to the strict standards of the applicable clinical trial regulations. In this systematic review, we list clinical data published between Jan 1, 2000 and Aug 14, 2021 on the safety and efficacy of phage therapy for difficult-to-treat bacterial infections, and provide an overview of trials and case studies on the use of phage therapy in several medical disciplines.
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ObjectType-Evidence Based Healthcare-1
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ISSN:1473-3099
1474-4457
1474-4457
DOI:10.1016/S1473-3099(21)00612-5