Restriction of human immunodeficiency virus type 1 by TRIM-CypA occurs with rapid kinetics and independently of cytoplasmic bodies, ubiquitin, and proteasome activity

TRIM-CypA is an owl monkey-specific variant of the retrovirus restriction factor TRIM5alpha. Here, we exploit its modular domain organization and cyclosporine sensitivity to probe the kinetics and mechanism of TRIM5-mediated restriction. Time of addition/withdrawal experiments reveal that inhibition...

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Bibliographic Details

Published in:	Journal of virology Vol. 79; no. 24; p. 15567
Main Authors:	Perez-Caballero, David, Hatziioannou, Theodora, Zhang, Fengwen, Cowan, Simone, Bieniasz, Paul D
Format:	Journal Article
Language:	English
Published:	United States 01.12.2005
Subjects:	Animals Cytoplasm - metabolism HIV-1 - genetics HIV-1 - metabolism Humans Kinetics Macaca mulatta Proteasome Endopeptidase Complex - metabolism Proteins - genetics Proteins - metabolism Ubiquitin - metabolism Ubiquitin-Protein Ligases
ISSN:	0022-538X
Online Access:	Get more information
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