Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

People with Down syndrome (DS) show clinical signs of accelerated ageing. Causative mechanisms remain unknown and hypotheses range from the (essentially untreatable) amplified-chromosomal-instability explanation, to potential actions of individual supernumerary chromosome-21 genes. The latter explan...

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Bibliographic Details
Published in:	EBioMedicine Vol. 94; p. 104692
Main Authors:	Murray, Aoife, Gough, Gillian, Cindrić, Ana, Vučković, Frano, Koschut, David, Borelli, Vincenzo, Petrović, Dražen J., Bekavac, Ana, Plećaš, Ante, Hribljan, Valentina, Brunmeir, Reinhard, Jurić, Julija, Pučić-Baković, Maja, Slana, Anita, Deriš, Helena, Frkatović, Azra, Groet, Jűrgen, O’Brien, Niamh L., Chen, Hong Yu, Yeap, Yee Jie, Delom, Frederic, Havlicek, Steven, Gammon, Luke, Hamburg, Sarah, Startin, Carla, D’Souza, Hana, Mitrečić, Dinko, Kero, Mijana, Odak, Ljubica, Krušlin, Božo, Krsnik, Željka, Kostović, Ivica, Foo, Jia Nee, Loh, Yuin-Han, Dunn, Norris Ray, de la Luna, Susana, Spector, Tim, Barišić, Ingeborg, Thomas, Michael S.C., Strydom, Andre, Franceschi, Claudio, Lauc, Gordan, Krištić, Jasminka, Alić, Ivan, Nižetić, Dean
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.08.2023 Elsevier
Subjects:	Adult Advanced Basic Science Ageing Aging Cell Differentiation Chromosome 21 Down syndrome Down Syndrome - genetics Down syndrome critical region Dyrk Kinases DYRK1A DYRK1A inhibitors Humans IgG glycan Induced Pluripotent Stem Cells Internal Medicine LaminB1 IgG glycan Ageing Chromosome 21 DYRK1A Down syndrome LaminB1 Down syndrome critical region DYRK1A inhibitors
ISSN:	2352-3964, 2352-3964
Online Access:	Get full text
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