FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage

Abnormal cytoplasmic accumulation of Fused in Sarcoma (FUS) in neurons defines subtypes of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). FUS is a member of the FET protein family that includes Ewing's sarcoma (EWS) and TATA-binding protein-associated factor 2...

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Vydané v:	The Journal of neuroscience Ročník 34; číslo 23; s. 7802
Hlavní autori:	Deng, Qiudong, Holler, Christopher J, Taylor, Georgia, Hudson, Kathryn F, Watkins, William, Gearing, Marla, Ito, Daisuke, Murray, Melissa E, Dickson, Dennis W, Seyfried, Nicholas T, Kukar, Thomas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 04.06.2014
Predmet:	Aminoglycosides - pharmacology Antibiotics, Antineoplastic - pharmacology Astrocytes - drug effects Astrocytes - metabolism Cells, Cultured Cytoplasm - drug effects Cytoplasm - metabolism DNA Damage - drug effects DNA Damage - physiology DNA-Activated Protein Kinase - metabolism Enediynes - pharmacology Frontotemporal Lobar Degeneration - metabolism Frontotemporal Lobar Degeneration - pathology Humans Immunoprecipitation Mutagens - pharmacology Mutation - genetics Neurons Nuclear Proteins - metabolism Phosphorylation - drug effects Receptors, Cytoplasmic and Nuclear - metabolism RNA-Binding Protein EWS - metabolism RNA-Binding Protein FUS - metabolism TATA-Binding Protein Associated Factors - metabolism Fused in Sarcoma (FUS) amyotrophic lateral sclerosis (ALS) phosphorylation DNA damage frontotemporal lobar degeneration (FTLD) cytoplasmic translocation
ISSN:	1529-2401, 1529-2401
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