Trends in Pulmonary Embolism Deaths Among Young Adults Aged 25 to 44 Years in the United States, 1999 to 2019

A concerning increase in mortality from acute pulmonary embolism (PE) in young adults in the United States has been reported. We extracted PE-related mortality rates (number of deaths per US population) from the Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Re...

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Vydané v:The American journal of cardiology Ročník 202; s. 169 - 175
Hlavní autori: Zuin, Marco, Bikdeli, Behnood, Armero, Andre, Porio, Nicole, Rigatelli, Gianluca, Bilato, Claudio, Piazza, Gregory
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Elsevier Inc 01.09.2023
Elsevier Limited
Predmet:
Adult
Adults
Age groups
Confidence intervals
Disease
Disease control
Embolism
Epidemiology
Ethnicity
Fatalities
Female
Gender
Hispanic people
Humans
Male
Mortality
Pacific Islander people
Pulmonary Embolism - mortality
Pulmonary embolisms
Race
Racial Groups
Rural areas
Statistical analysis
Statistical significance
Trends
United States - epidemiology
Urbanization
Womens health
Young adults
United States
United States > US
Alaska
ISSN:0002-9149, 1879-1913, 1879-1913
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Shrnutí:A concerning increase in mortality from acute pulmonary embolism (PE) in young adults in the United States has been reported. We extracted PE-related mortality rates (number of deaths per US population) from the Centers for Disease Control and Prevention Wide‐Ranging Online Data for Epidemiologic Research database from 1999 to 2019, focusing on subjects aged 25 to 44 years. Age‐adjusted mortality rates (AAMRs) were assessed using the Joinpoint regression modeling and expressed as the estimated average annual percentage change (AAPC) with relative 95% confidence intervals (95% CIs) and stratified by urbanization, gender, age, and race. Between 1999 and 2019, the AAMR from acute PE in US adults aged 25 to 44 years linearly increased without any difference between genders (AAPC +1.5%, 95% CI 1.2 to 1.8, p <0.001). AAMR increase was more pronounced in American-Indians/Alaska Natives and in Asian/Pacific Islanders (AAPC +2.5%, 95% CI 1.6 to 3.4, p <0.001), Whites (AAPC +1.7%, 95% CI 1.4 to 2.0, p <0.001), Latinx/Hispanic patients (AAPC +1.7%, 95% CI 0.6 to 3.0, p = 0.003), and residents of rural areas (AAPC +2.4%, 95% CI 1.9 to 2.8, p <0.001). A higher AAMR (4.02 per 100,000 residents, 95% CI 3.90 to 4.15) and absolute number of PE-related deaths were observed in the South. PE-related mortality in adults aged 25 to 44 years has increased over the last 2 decades in the United States. Stratification by race, ethnicity, urbanization, and census region showed ethnoracial and regional disparities that will require further evaluation and remedy.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2023.06.075