Immunohistochemical and morphometrical evaluation of well-differentiated thyroid tumor of uncertain malignant potential

Context: Well-differentiated tumor of uncertain malignant potential (WDT-UMP) were encapsulated follicular pattern tumors with diffuse equivocal or focal unequivocal papillary thyroid carcinoma (PTC) type nuclear changes without definite invasion. These tumors are suggested to be borderline in its n...

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Vydáno v:Indian journal of pathology & microbiology Ročník 62; číslo 1; s. 17 - 23
Hlavní autoři: Mohamed, Dareen, Shamlola, Maha
Médium: Journal Article
Jazyk:angličtina
Vydáno: India Wolters Kluwer India Pvt. Ltd 01.01.2019
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Wolters Kluwer Medknow Publications
Témata:
Benign
Biomarkers, Tumor - analysis
Carcinoma
CD56 antigen
CD56 Antigen - analysis
Cell adhesion & migration
Cell Differentiation
CK19
Diagnosis
Gene expression
Humans
Immunohistochemistry
Keratin-19 - analysis
Lesions
Markers
Membrane Proteins - analysis
Morphometry
Papillary thyroid carcinoma
Paraffin Embedding
Statistical analysis
Statistical tests
Studies
Thyroid
Thyroid cancer
Thyroid diseases
Thyroid Gland - pathology
Thyroid Neoplasms - diagnosis
Thyroid Neoplasms - pathology
Tumors
Variance analysis
WDT-UMP
United States > US
morphometry
papillary thyroid carcinoma
CK19
WDT-UMP
ISSN:0377-4929, 0974-5130, 0974-5130
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Shrnutí:Context: Well-differentiated tumor of uncertain malignant potential (WDT-UMP) were encapsulated follicular pattern tumors with diffuse equivocal or focal unequivocal papillary thyroid carcinoma (PTC) type nuclear changes without definite invasion. These tumors are suggested to be borderline in its nature. Immunohistochemistry by CD56, P63, and CK19 are common markers used in differentiation between benign and malignant thyroid tumor. Computerized nuclear morphometry is an inexpensive objective and reproducible tool to evaluate histological features of thyroid tumors. Aims: To categorize WDT-UMP using combined nuclear morphometry and immunohistochemistry of CD56, P63, and CK19. Subjects and Methods: We used CD56, P63, and CK19 immunostaining and mean nuclear area and perimeter morphometry on 20 cases of WDT-UMP, 25 cases malignant thyroid tumors, and 25 cases benign thyroid lesions. Statistical Analysis Used: Student's t-test (Unpaired), analysis of variance (ANOVA) test, and Chi-square tests by SPSS V. 20. Results: Significant differences were obtained between WDT-UMP and benign group according to the three markers, but no significant difference between WDT-UMP and malignant group. The mean nuclear area and mean nuclear perimeter were significantly higher in WDT-UMP group in comparison with the benign group while there were no significant differences with the malignant group. Conclusion: WDT-UMP are intermediate lesions differing from benign lesions of the thyroid and sharing some criteria with PTC to a certain extent.
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ISSN:0377-4929
0974-5130
0974-5130
DOI:10.4103/IJPM.IJPM_199_18