MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction

Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to amino acid restriction, which impede the latter’s clinical development. Here we show that MAPK signaling activation in asparagine-restricted...

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Bibliographic Details
Published in:	EMBO reports Vol. 22; no. 3; pp. e51436 - n/a
Main Authors:	Pathria, Gaurav, Verma, Sachin, Yin, Jun, Scott, David A, Ronai, Ze’ev A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.03.2021 Springer Nature B.V John Wiley and Sons Inc
Subjects:	Acid resistance Adaptation Amino acids Asparagine ATF4 Cancer Cell activation Cell growth Cell Line, Tumor Cell Proliferation c‐MYC Degradation EMBO03 EMBO21 Glycogen Synthase Kinase 3 Humans MAP kinase MAPK Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Melanoma Melanoma - genetics mTORC1 Myc protein Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Signal Transduction Signaling melanoma MAPK c-MYC mTORC1 ATF4
ISSN:	1469-221X, 1469-3178, 1469-3178
Online Access:	Get full text
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