Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium

Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, an emerging virus that utilizes host proteins ACE2 and TMPRSS2 as entry factors. Understanding the factors affecting the pattern and levels of expression of these genes is important for deeper understanding of SARS-CoV-2 tropism and pathog...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 5139 - 18
Main Authors:	Sajuthi, Satria P., DeFord, Peter, Li, Yingchun, Jackson, Nathan D., Montgomery, Michael T., Everman, Jamie L., Rios, Cydney L., Pruesse, Elmar, Nolin, James D., Plender, Elizabeth G., Wechsler, Michael E., Mak, Angel C. Y., Eng, Celeste, Salazar, Sandra, Medina, Vivian, Wohlford, Eric M., Huntsman, Scott, Nickerson, Deborah A., Germer, Soren, Zody, Michael C., Abecasis, Gonçalo, Kang, Hyun Min, Rice, Kenneth M., Kumar, Rajesh, Oh, Sam, Rodriguez-Santana, Jose, Burchard, Esteban G., Seibold, Max A.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 12.10.2020 Nature Portfolio
Subjects:	13/106 38 38/91 631/208/200 631/337/2019 631/80/304 692/699/255/2514 Angiotensin-Converting Enzyme 2 Betacoronavirus - physiology Child Coronavirus Infections - metabolism Coronavirus Infections - pathology Coronavirus Infections - virology COVID-19 Epithelial Cells - metabolism Gene Expression Profiling Gene Expression Regulation Genetic Variation Host-Pathogen Interactions Humanities and Social Sciences Humans Inflammation Interferons - metabolism Interleukin-13 - metabolism Middle Aged multidisciplinary Nasal Mucosa - metabolism Nasal Mucosa - pathology Pandemics Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - metabolism Pneumonia, Viral - pathology Pneumonia, Viral - virology SARS-CoV-2 Science Science (multidisciplinary) Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Virus Internalization
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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