Proinflammatory state, hepcidin, and anemia in older persons

In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron stat...

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Bibliographic Details
Published in:	Blood Vol. 115; no. 18; p. 3810
Main Authors:	Ferrucci, Luigi, Semba, Richard D, Guralnik, Jack M, Ershler, William B, Bandinelli, Stefania, Patel, Kushang V, Sun, Kai, Woodman, Richard C, Andrews, Nancy C, Cotter, Robert J, Ganz, Tomas, Nemeth, Elizabeta, Longo, Dan L
Format:	Journal Article
Language:	English
Published:	United States 06.05.2010
Subjects:	Aged Aged, 80 and over Aging Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - urine Antimicrobial Cationic Peptides - urine Biomarkers - blood Biomarkers - urine C-Reactive Protein - metabolism Female Hepcidins Humans Inflammation - blood Inflammation - immunology Inflammation - urine Inflammation Mediators - blood Interleukin-1beta - blood Interleukin-6 - blood Italy Male Tumor Necrosis Factor-alpha - blood Italy
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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