Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort

•An altered fecal microbiome was associated with the Alzheimer’s disease (AD).•The depleted Firmicutes and enriched Proteobacteria linked with severity of AD.•Enterobacteriaceae was associated with the presence and progression of AD.•Models based on fecal microbiota discriminate AD from aMCI and hea...

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Veröffentlicht in:	Brain, behavior, and immunity Jg. 80; S. 633 - 643
Hauptverfasser:	Liu, Ping, Wu, Li, Peng, Guoping, Han, Yuqiu, Tang, Ruiqi, Ge, Jianping, Zhang, Lijiang, Jia, Longfei, Yue, Siqing, Zhou, Kai, Li, Lanjuan, Luo, Benyan, Wang, Baohong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Inc 01.08.2019
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - genetics Alzheimer Disease - microbiology Alzheimer’s disease Amnesia - diagnosis Amnesia - microbiology Amnestic mild cognitive impairment Area Under Curve Asian Continental Ancestry Group Biomarkers Brain - physiopathology China Cognition Cognitive Dysfunction - diagnosis Cognitive Dysfunction - genetics Cognitive Dysfunction - microbiology Cohort Studies Cross-Sectional Studies Feces - microbiology Female Gastrointestinal Microbiome - genetics Humans Male Microbiome marker Neuropsychological Tests Prospective Studies RNA, Ribosomal, 16S - genetics China Microbiome marker Alzheimer’s disease Amnestic mild cognitive impairment
ISSN:	0889-1591, 1090-2139, 1090-2139
Online-Zugang:	Volltext
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