MoonDB 2.0: an updated database of extreme multifunctional and moonlighting proteins

Abstract MoonDB 2.0 (http://moondb.hb.univ-amu.fr/) is a database of predicted and manually curated extreme multifunctional (EMF) and moonlighting proteins, i.e. proteins that perform multiple unrelated functions. We have previously shown that such proteins can be predicted through the analysis of t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nucleic acids research Jg. 47; H. D1; S. D398 - D402
Hauptverfasser: Ribeiro, Diogo M, Briere, Galadriel, Bely, Benoit, Spinelli, Lionel, Brun, Christine
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Oxford University Press 08.01.2019
Schlagworte:
Animals
Caenorhabditis elegans - genetics
Data Curation
Database Issue
Databases, Protein
Drosophila melanogaster - genetics
Gene Ontology
Humans
Life Sciences
Mice
Molecular Sequence Annotation
Protein Interaction Mapping
Quantitative Methods
User-Computer Interface
Yeasts - genetics
UniProt Knowl-edgebase (UniProtKB)
MoonDB 2.0
ISSN:0305-1048, 1362-4962, 1362-4962
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Abstract MoonDB 2.0 (http://moondb.hb.univ-amu.fr/) is a database of predicted and manually curated extreme multifunctional (EMF) and moonlighting proteins, i.e. proteins that perform multiple unrelated functions. We have previously shown that such proteins can be predicted through the analysis of their molecular interaction subnetworks, their functional annotations and their association to distinct groups of proteins that are involved in unrelated functions. In MoonDB 2.0, we updated the set of human EMF proteins (238 proteins), using the latest functional annotations and protein–protein interaction networks. Furthermore, for the first time, we applied our method to four additional model organisms - mouse, fly, worm and yeast - and identified 54 novel EMF proteins in these species. In addition to novel predictions, this update contains 63 human and yeast proteins that were manually curated from literature, including descriptions of moonlighting functions and associated references. Importantly, MoonDB’s interface was fully redesigned and improved, and its entries are now cross-referenced in the UniProt Knowledgebase (UniProtKB). MoonDB will be updated once a year with the novel EMF candidates calculated from the latest available protein interactions and functional annotations.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Present address: Galadriel Briere, Bordeaux Sciences Agro, 33175 Gradignan, France.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gky1039