Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gamet...

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Bibliographic Details
Published in:	Translational psychiatry Vol. 7; no. 1; p. e1019
Main Authors:	Janecka, M, Mill, J, Basson, M A, Goriely, A, Spiers, H, Reichenberg, A, Schalkwyk, L, Fernandes, C
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.01.2017 Nature Publishing Group
Subjects:	38 38/23 631/208/2489 631/477/2811 Age Factors Autistic Disorder - epidemiology Autistic Disorder - genetics Behavioral Sciences Biological Psychology Epigenesis, Genetic Humans Medicine Medicine & Public Health Neurodevelopmental disorders Neurodevelopmental Disorders - epidemiology Neurodevelopmental Disorders - genetics Neurosciences Paternal Age Pharmacotherapy Psychiatry Review Risk Factors Schizophrenia - epidemiology Schizophrenia - genetics
ISSN:	2158-3188, 2158-3188
Online Access:	Get full text
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