Genetic and environmental influences interact with age and sex in shaping the human methylome

The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance expl...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; pp. 11115 - 13
Main Authors:	van Dongen, Jenny, Nivard, Michel G., Willemsen, Gonneke, Hottenga, Jouke-Jan, Helmer, Quinta, Dolan, Conor V., Ehli, Erik A., Davies, Gareth E., van Iterson, Maarten, Breeze, Charles E., Beck, Stephan, Suchiman, H. Eka, Jansen, Rick, van Meurs, Joyce B., Heijmans, Bastiaan T., Slagboom, P. Eline, Boomsma, Dorret I.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.04.2016 Nature Publishing Group Nature Portfolio
Subjects:	631/208/212/177 631/337/176/1988 Adolescent Adult Age Age Factors Aging - genetics Blood Child, Preschool CpG Islands Deoxyribonucleic acid Disease DNA DNA Methylation Environmental effects Epidemiology Epigenetics Female Gender differences Gene-Environment Interaction Genetic diversity Genome, Human Genomes Humanities and Social Sciences Humans Inheritance Patterns Leukocytes Male Metabolism Metabolites multidisciplinary Phenotype Polymorphism, Single Nucleotide Science Science (multidisciplinary) Sex Factors Smoking - physiopathology Twins Twins, Dizygotic - genetics Twins, Monozygotic - genetics Netherlands
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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