Cognitive impairment in folate-deficient rats corresponds to depleted brain phosphatidylcholine and is prevented by dietary methionine without lowering plasma homocysteine

Poor folate status is associated with cognitive decline and dementia in older adults. Although impaired brain methylation activity and homocysteine toxicity are widely thought to account for this association, how folate deficiency impairs cognition is uncertain. To better define the role of folate d...

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Bibliographic Details
Published in:	The Journal of nutrition Vol. 138; no. 12; p. 2502
Main Authors:	Troen, Aron M, Chao, Wei-Hsun, Crivello, Natalia A, D'Anci, Kristen E, Shukitt-Hale, Barbara, Smith, Don E, Selhub, Jacob, Rosenberg, Irwin H
Format:	Journal Article
Language:	English
Published:	United States 01.12.2008
Subjects:	Animals Brain - metabolism Cognition Disorders - blood Cognition Disorders - etiology Cognition Disorders - metabolism Cognition Disorders - prevention & control Dietary Supplements Folic Acid Deficiency - complications Folic Acid Deficiency - diet therapy Folic Acid Deficiency - metabolism Folic Acid Deficiency - psychology Homocystine - blood Lecithins - metabolism Male Maze Learning Methionine - administration & dosage Psychomotor Performance Rats Rats, Sprague-Dawley S-Adenosylhomocysteine - metabolism S-Adenosylmethionine - metabolism
ISSN:	1541-6100, 1541-6100
Online Access:	Get more information
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