Crosstalk between Cell Adhesion Complexes in Regulation of Mechanotransduction

Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crossta...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	BioEssays Ročník 42; číslo 11; s. e2000119 - n/a
Hlavní autori:	Zuidema, Alba, Wang, Wei, Sonnenberg, Arnoud
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Wiley Subscription Services, Inc 01.11.2020
Predmet:	Actin Adaptor proteins Adherens junctions Adhesion Biological activity cadherin Cadherins Cell adhesion Cell adhesion & migration cell‐matrix cell–cell Clathrin Crosstalk Cytoskeleton Desmosomes Filaments Hemidesmosomes integrin Integrins Intermediate filaments landscapes Lattices ligands Mechanotransduction microfilaments physiology tetraspanin Traction force cell-matrix clathrin tetraspanin mechanotransduction cadherin integrin cell-cell
ISSN:	0265-9247, 1521-1878, 1521-1878
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Popis
Shrnutí:	Physical forces regulate numerous biological processes during development, physiology, and pathology. Forces between the external environment and intracellular actin cytoskeleton are primarily transmitted through integrin‐containing focal adhesions and cadherin‐containing adherens junctions. Crosstalk between these complexes is well established and modulates the mechanical landscape of the cell. However, integrins and cadherins constitute large families of adhesion receptors and form multiple complexes by interacting with different ligands, adaptor proteins, and cytoskeletal filaments. Recent findings indicate that integrin‐containing hemidesmosomes oppose force transduction and traction force generation by focal adhesions. The cytolinker plectin mediates this crosstalk by coupling intermediate filaments to the actin cytoskeleton. Similarly, cadherins in desmosomes might modulate force generation by adherens junctions. Moreover, mechanotransduction can be influenced by podosomes, clathrin lattices, and tetraspanin‐enriched microdomains. This review discusses mechanotransduction by multiple integrin‐ and cadherin‐based cell adhesion complexes, which together with the associated cytoskeleton form an integrated network that allows cells to sense, process, and respond to their physical environment. Cells assemble integrin‐ and cadherin‐containing adhesions that mediate interactions with the extracellular matrix and neighboring cells, respectively. In this review, the extensive crosstalk between distinct cell adhesions that regulates mechanotransduction is discussed.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0265-9247 1521-1878 1521-1878
DOI:	10.1002/bies.202000119