YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy

The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently activated during the growth and progression of many solid tumors, including lung, colorectal, breast, pancreatic, and liver carcinomas as well as melanoma and glioma. YAP/TAZ bind to TEAD‐family co‐activators to drive...

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Bibliographic Details
Published in:	BioEssays Vol. 42; no. 5; pp. e1900162 - n/a
Main Author:	Thompson, Barry J.
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.05.2020
Subjects:	1-Phosphatidylinositol 3-kinase Activation AKT protein Brain tumors Breast Breast carcinoma breasts Cancer cancer therapy Cell migration Cell survival cell viability Chemotherapy drug therapy Fibroblasts G protein-coupled receptors Glioma Growth factors Hippo pathway Immunotherapy Invasiveness liver lungs Melanoma Metastases Metastasis neoplasm cells Pancreas Pancreatic carcinoma Radiation therapy radiotherapy Solid tumors Stiffening tissue growth transcription (genetics) Transcription factors Tumors Upstream YAP/TAZ Yes-associated protein cancer tissue growth Hippo pathway YAP/TAZ
ISSN:	0265-9247, 1521-1878, 1521-1878
Online Access:	Get full text
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