More Severe Hypercoagulable State in Acute COVID-19 Pneumonia as Compared With Other Pneumonia

To conduct a comprehensive evaluation of coagulation profiles—via traditional and whole blood thromboelastometry tests—in coronavirus disease 2019 (COVID-19)–positive vs COVID-19–negative patients admitted to medical wards for acute pneumonia. We enrolled all consecutive patients admitted to interna...

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Published in:Mayo Clinic proceedings. Innovations, quality & outcomes Vol. 4; no. 6; pp. 696 - 702
Main Authors: Spiezia, Luca, Campello, Elena, Cola, Marco, Poletto, Francesco, Cerruti, Lorenzo, Poretto, Anna, Simion, Chiara, Cattelan, Annamaria, Vettor, Roberto, Simioni, Paolo
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01.12.2020
Elsevier
Subjects:
Original
CFT
COVID-19
CT
MCF
SARS-CoV-2
COVID-19, coronavirus disease 2019
CFT, clot formation time
CT, clotting time
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
MCF, maximum clot firmness
ISSN:2542-4548, 2542-4548
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Summary:To conduct a comprehensive evaluation of coagulation profiles—via traditional and whole blood thromboelastometry tests—in coronavirus disease 2019 (COVID-19)–positive vs COVID-19–negative patients admitted to medical wards for acute pneumonia. We enrolled all consecutive patients admitted to internal medicine wards of Padova University Hospital between 7 March and 30 April, 2020, for COVID-19–related pneumonia (cases) vs non–COVID-19 pneumonia (controls). A group of healthy individuals acted as baseline for thromboelastometry parameters. Fifty-six cases (mean age, 64±15 years; male/female, 37/19) and 56 controls (mean age, 76±11 years; male/female, 35/21) were enrolled. Cases and controls exhibited markedly hypercoagulable thromboelastometry profiles vs healthy individuals, mainly characterized by a significantly shorter propagation phase of coagulation (clot formation time) and significantly increased maximum clot firmness (P<.001 for all comparisons). Patients with COVID-19 pneumonia had significantly shorter clot formation time and higher maximum clot firmness (P<.01 and P<.05, respectively, for all comparisons) than did controls. Patients admitted to internal medicine wards for COVID-19 pneumonia presented a markedly prothrombotic state, which seems peculiar to COVID-19 rather than pneumonia itself.
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ISSN:2542-4548
2542-4548
DOI:10.1016/j.mayocpiqo.2020.09.002