Dopamine modulates involuntary attention shifting and reorienting: an electromagnetic study

Objective: Dopaminergic function has been closely associated with attentional performance, but its precise role has remained elusive. Methods: Electrophysiological and behavioral methods were used to assess the effects of dopamine D2-receptor antagonist haloperidol on involuntary attention shifting...

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Bibliographic Details
Published in:Clinical neurophysiology Vol. 113; no. 12; pp. 1894 - 1902
Main Authors: Kähkönen, Seppo, Ahveninen, Jyrki, Pekkonen, Eero, Kaakkola, Seppo, Huttunen, Juha, Ilmoniemi, Risto J, Jääskeläinen, Iiro P
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 01.12.2002
Elsevier Science
Subjects:
Activity levels. Psychomotricity
Adult
Analysis of Variance
Attention
Attention - drug effects
Attention - physiology
Auditory event-related responses
Biological and medical sciences
Cross-Over Studies
Dopamine
Dopamine - physiology
Double-Blind Method
Electroencephalography
Electroencephalography - drug effects
Electroencephalography - methods
Electromagnetic Phenomena
Female
Fundamental and applied biological sciences. Psychology
Haloperidol
Haloperidol - pharmacology
Humans
Magnetoencephalography
Magnetoencephalography - drug effects
Magnetoencephalography - methods
Male
Orientation - drug effects
Orientation - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Reaction Time - drug effects
Reaction Time - physiology
Vigilance. Attention. Sleep
Electroencephalography
Dopamine
Haloperidol
Magnetoencephalography
Auditory event-related responses
Attention
Human
High resolution
Dopamine antagonist
Exploration
Cognition
Butyrophenone derivatives
Crossover study
Electrodiagnosis
Randomization
D2 Dopamine receptor
Double blind study
Biological effect
ISSN:1388-2457, 1872-8952
Online Access:Get full text
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Summary:Objective: Dopaminergic function has been closely associated with attentional performance, but its precise role has remained elusive. Methods: Electrophysiological and behavioral methods were used to assess the effects of dopamine D2-receptor antagonist haloperidol on involuntary attention shifting using a randomized, double-blind, placebo-controlled cross-over design. Eleven subjects were instructed to discriminate equiprobable 200 and 400 ms tones in a forced-choice reaction-time (RT) task during simultaneous measurement of whole-head magnetoencephalography and high-resolution electroencephalography. Results: Occasional changes in task-irrelevant tone frequency (10% increase or decrease) caused marked distraction on behavioral performance, as shown by significant RT increases to deviant stimuli and subsequent standard tones. Furthermore, while the standard tones elicited distinct P1–N1–P2–N2–P3 waveforms, deviant tones elicited additional mismatch negativity (MMN), P3a, and reorienting negativity (RON) responses, indexing brain events associated with involuntary attention shifting. While haloperidol did not affect the source loci of the responses of magnetic N1 and MMN, the amplitude of the electric P3a and that of RON were significantly reduced and the latency of magnetic RON were delayed following haloperidol administration. Conclusions: The present results suggest that dopamine modulates involuntary attention shifting to task-irrelevant deviant events. It appears that dopamine may disrupt the subsequent re-orienting efforts to the relevant task after distraction.
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ISSN:1388-2457
1872-8952
DOI:10.1016/S1388-2457(02)00305-X