Dopamine modulates involuntary attention shifting and reorienting: an electromagnetic study

Objective: Dopaminergic function has been closely associated with attentional performance, but its precise role has remained elusive. Methods: Electrophysiological and behavioral methods were used to assess the effects of dopamine D2-receptor antagonist haloperidol on involuntary attention shifting...

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Vydáno v:	Clinical neurophysiology Ročník 113; číslo 12; s. 1894 - 1902
Hlavní autoři:	Kähkönen, Seppo, Ahveninen, Jyrki, Pekkonen, Eero, Kaakkola, Seppo, Huttunen, Juha, Ilmoniemi, Risto J, Jääskeläinen, Iiro P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Shannon Elsevier Ireland Ltd 01.12.2002 Elsevier Science
Témata:	Activity levels. Psychomotricity Adult Analysis of Variance Attention Attention - drug effects Attention - physiology Auditory event-related responses Biological and medical sciences Cross-Over Studies Dopamine Dopamine - physiology Double-Blind Method Electroencephalography Electroencephalography - drug effects Electroencephalography - methods Electromagnetic Phenomena Female Fundamental and applied biological sciences. Psychology Haloperidol Haloperidol - pharmacology Humans Magnetoencephalography Magnetoencephalography - drug effects Magnetoencephalography - methods Male Orientation - drug effects Orientation - physiology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Reaction Time - drug effects Reaction Time - physiology Vigilance. Attention. Sleep Electroencephalography Dopamine Haloperidol Magnetoencephalography Auditory event-related responses Attention Human High resolution Dopamine antagonist Exploration Cognition Butyrophenone derivatives Crossover study Electrodiagnosis Randomization D2 Dopamine receptor Double blind study Biological effect
ISSN:	1388-2457, 1872-8952
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Popis
Shrnutí:	Objective: Dopaminergic function has been closely associated with attentional performance, but its precise role has remained elusive. Methods: Electrophysiological and behavioral methods were used to assess the effects of dopamine D2-receptor antagonist haloperidol on involuntary attention shifting using a randomized, double-blind, placebo-controlled cross-over design. Eleven subjects were instructed to discriminate equiprobable 200 and 400 ms tones in a forced-choice reaction-time (RT) task during simultaneous measurement of whole-head magnetoencephalography and high-resolution electroencephalography. Results: Occasional changes in task-irrelevant tone frequency (10% increase or decrease) caused marked distraction on behavioral performance, as shown by significant RT increases to deviant stimuli and subsequent standard tones. Furthermore, while the standard tones elicited distinct P1–N1–P2–N2–P3 waveforms, deviant tones elicited additional mismatch negativity (MMN), P3a, and reorienting negativity (RON) responses, indexing brain events associated with involuntary attention shifting. While haloperidol did not affect the source loci of the responses of magnetic N1 and MMN, the amplitude of the electric P3a and that of RON were significantly reduced and the latency of magnetic RON were delayed following haloperidol administration. Conclusions: The present results suggest that dopamine modulates involuntary attention shifting to task-irrelevant deviant events. It appears that dopamine may disrupt the subsequent re-orienting efforts to the relevant task after distraction.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	1388-2457 1872-8952
DOI:	10.1016/S1388-2457(02)00305-X