Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics

Purpose Describe CYP2C19 sequencing results in the largest series of clopidogrel-treated cases with stent thrombosis (ST), the closest clinical phenotype to clopidogrel resistance. Evaluate the impact of CYP2C19 genetic variation detected by next-generation sequencing (NGS) with comprehensive annota...

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Veröffentlicht in:	Cardiovascular drugs and therapy Jg. 35; H. 3; S. 549 - 559
Hauptverfasser:	Morales-Rosado, Joel A., Goel, Kashish, Zhang, Lingxin, Åkerblom, Axel, Baheti, Saurabh, Black, John L., Eriksson, Niclas, Wallentin, Lars, James, Stefan, Storey, Robert F., Goodman, Shaun G., Jenkins, Gregory D., Eckloff, Bruce W., Bielinski, Suzette J., Sicotte, Hugues, Johnson, Stephen, Roger, Veronique L., Wang, Liewei, Weinshilboum, Richard, Klee, Eric W., Rihal, Charanjit S., Pereira, Naveen L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.06.2021 Springer Nature B.V
Schlagworte:	Aged Alleles Annotations Cardiology Clopidogrel Clopidogrel - administration & dosage Clopidogrel - pharmacokinetics CYP2C19 Cytochrome P-450 CYP2C19 - genetics Diabetes mellitus Drug Resistance - genetics Evaluation Exome - genetics Female Genetic diversity Heterozygotes Humans Impact resistance Implants Intronic Introns Male Medicine Medicine & Public Health Middle Aged Next-generation sequencing Original Article Pharmacogenomics Phenotypes Platelet aggregation Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacokinetics Protein expression Proteins Stent thrombosis Stents Thrombosis Thrombosis - prevention & control Translational medicine Stent thrombosis CYP2C19 Intronic Translational medicine Pharmacogenomics
ISSN:	0920-3206, 1573-7241, 1573-7241
Online-Zugang:	Volltext
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