Comparison of quantitative whole body PET parameters on [68Ga]Ga-PSMA-11 PET/CT using ordered Subset Expectation Maximization (OSEM) vs. bayesian penalized likelihood (BPL) reconstruction algorithms in men with metastatic castration-resistant prostate cancer

Background PSMA PET/CT is a predictive and prognostic biomarker for determining response to [ 177 Lu]Lu-PSMA-617 in patients with metastatic castration resistant prostate cancer (mCRPC). Thresholds defined to date may not be generalizable to newer image reconstruction algorithms. Bayesian penalized...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer imaging Jg. 24; H. 1; S. 57 - 8
Hauptverfasser: Ayati, Narjess, McIntosh, Lachlan, Buteau, James, Alipour, Ramin, Pudis, Michal, Daw, Nicholas, Jackson, Price, Hofman, Michael S.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 06.05.2024
BioMed Central Ltd
BMC
Schlagworte:
Aged
Aged, 80 and over
Algorithms
Bayes Theorem
Bayesian penalized likelihood (BPL)
Cable television broadcasting industry
Cancer Research
Comparative analysis
Dipeptides - therapeutic use
Edetic Acid - analogs & derivatives
Electrical equipment and supplies industry
Gallium Isotopes
Gallium Radioisotopes
Humans
Image Processing, Computer-Assisted - methods
Image reconstruction
Imaging
Male
Medicine
Medicine & Public Health
Metastasis
Metastatic castration-resistant prostate cancer (mCRPC)
Middle Aged
Neoplasm Metastasis
Noise control
Nuclear Medicine
Oligopeptides
Oncology
Ordered subset expectation maximization (OSEM)
PET imaging
Positron Emission Tomography Computed Tomography - methods
Prostate cancer
Prostatic Neoplasms, Castration-Resistant - diagnostic imaging
Prostatic Neoplasms, Castration-Resistant - pathology
PSMA PET/CT
Radiology
Radiopharmaceuticals
Research Article
Retrospective Studies
Sport-utility vehicles
Whole Body Imaging - methods
United States
Bayesian penalized likelihood (BPL)
Ordered subset expectation maximization (OSEM)
Metastatic castration-resistant prostate cancer (mCRPC)
PSMA PET/CT
Image reconstruction
ISSN:1470-7330, 1740-5025, 1470-7330
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Background PSMA PET/CT is a predictive and prognostic biomarker for determining response to [ 177 Lu]Lu-PSMA-617 in patients with metastatic castration resistant prostate cancer (mCRPC). Thresholds defined to date may not be generalizable to newer image reconstruction algorithms. Bayesian penalized likelihood (BPL) reconstruction algorithm is a novel reconstruction algorithm that may improve contrast whilst preventing introduction of image noise. The aim of this study is to compare the quantitative parameters obtained using BPL and the Ordered Subset Expectation Maximization (OSEM) reconstruction algorithms. Methods Fifty consecutive patients with mCRPC who underwent [ 68 Ga]Ga-PSMA-11 PET/CT using OSEM reconstruction to assess suitability for [ 177 Lu]Lu-PSMA-617 therapy were selected. BPL algorithm was then used retrospectively to reconstruct the same PET raw data. Quantitative and volumetric measurements such as tumour standardised uptake value (SUV)max, SUVmean and Molecular Tumour Volume (MTV-PSMA) were calculated on both reconstruction methods. Results were compared (Bland-Altman, Pearson correlation coefficient) including subgroups with low and high-volume disease burdens (MTV-PSMA cut-off 40 mL). Results The SUVmax and SUVmean were higher, and MTV-PSMA was lower in the BPL reconstructed images compared to the OSEM group, with a mean difference of 8.4 (17.5%), 0.7 (8.2%) and − 21.5 mL (-3.4%), respectively. There was a strong correlation between the calculated SUVmax, SUVmean, and MTV-PSMA values in the OSEM and BPL reconstructed images (Pearson r values of 0.98, 0.99, and 1.0, respectively). No patients were reclassified from low to high volume disease or vice versa when switching from OSEM to BPL reconstruction. Conclusions [ 68 Ga]Ga-PSMA-11 PET/CT quantitative and volumetric parameters produced by BPL and OSEM reconstruction methods are strongly correlated. Differences are proportional and small for SUVmean, which is used as a predictive biomarker. Our study suggests that both reconstruction methods are acceptable without clinical impact on quantitative or volumetric findings. For longitudinal comparison, committing to the same reconstruction method would be preferred to ensure consistency.
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-024-00702-x