Retinal Capillary Plexus Pattern and Density from Fovea to Periphery Measured in Healthy Eyes with Swept-Source Optical Coherence Tomography Angiography

Optical coherence tomography angiography is evolving towards wider fields of view. As single widefield acquisitions have a lower resolution, preventing an accurate segmentation of vascular plexuses in the periphery, we examined the retinal vascularisation from the macula to the periphery in all reti...

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Vydáno v:	Scientific reports Ročník 10; číslo 1; s. 1474
Hlavní autoři:	Lavia, Carlo, Mecê, Pedro, Nassisi, Marco, Bonnin, Sophie, Marie-Louise, Jennifer, Couturier, Aude, Erginay, Ali, Tadayoni, Ramin, Gaudric, Alain
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 30.01.2020 Nature Publishing Group
Témata:	692/308 692/698 Adult Angiography Capillaries - anatomy & histology Capillaries - diagnostic imaging Cell density Diabetes mellitus Diabetic retinopathy Eye Female Fovea Centralis - blood supply Fovea Centralis - diagnostic imaging Human health and pathology Humanities and Social Sciences Humans Image processing Life Sciences Male Medical imaging multidisciplinary Retina Retina - diagnostic imaging Retinal Vessels - anatomy & histology Retinal Vessels - diagnostic imaging Retinopathy Science Science (multidisciplinary) Segmentation Sensory Organs Tomography Tomography, Optical Coherence - methods
ISSN:	2045-2322, 2045-2322
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Shrnutí:	Optical coherence tomography angiography is evolving towards wider fields of view. As single widefield acquisitions have a lower resolution, preventing an accurate segmentation of vascular plexuses in the periphery, we examined the retinal vascularisation from the macula to the periphery in all retinal quadrants, using 3 × 3-mm volume scans, to obtain montages with sufficient image resolution up to 11 mm from the foveal centre. Images were qualitatively and quantitatively analysed, using C- and B-scan approaches to calculate the capillary density (CD) and the interplexus distance (IPD). Three vascular plexuses ( i.e ., superficial vascular plexus: SVP, intermediate capillary plexus: ICP, and deep capillary plexus: DCP) were observed up to the mid-periphery in all sectors. The CD of the SVP decreased from about 5 mm of eccentricity, along with ganglion cell density decrease. The CD of the ICP progressively decreased from the fovea towards the periphery, along with the retinal thinning and then vanished from 8 to 9 mm of eccentricity, becoming undetectable beyond. This ICP disappearance resulted in an increased IPD between the SVP and the DCP in an area known to be frequently affected by capillary drop-out in diabetic retinopathy. The DCP only showed a slightly decreased CD towards the retinal periphery.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC6992636
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-020-58359-y