Dysregulation of Protein Kinase C in Adult Depression and Suicide: Evidence From Postmortem Brain Studies

Abstract Background Several lines of evidence suggest the abnormalities of protein kinase C (PKC) signaling system in mood disorders and suicide based primarily on the studies of PKC and its isozymes in the platelets and postmortem brain of depressed and suicidal subjects. In this study, we examined...

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Bibliographic Details
Published in:	The international journal of neuropsychopharmacology Vol. 24; no. 5; pp. 400 - 408
Main Authors:	Pandey, Ghanshyam N, Sharma, Anuradha, Rizavi, Hooriyah S, Ren, Xinguo
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 01.05.2021
Subjects:	Adult Autopsy Brain research Depression, Mental Depressive Disorder, Major - enzymology Development and progression Female Health aspects Humans Isoenzymes Isoenzymes - metabolism Kinases Male Middle Aged Physiological aspects Prefrontal Cortex - enzymology Protein biosynthesis Protein expression Protein Kinase C - metabolism Protein kinases Proteins Regular s RNA, Messenger - metabolism Suicidal behavior Suicide, Completed Suicides & suicide attempts Young Adult United States PKC postmortem brain PKC isozymes depression prefrontal cortex suicide
ISSN:	1461-1457, 1469-5111, 1469-5111
Online Access:	Get full text
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