Missing heritability: is the gap closing? An analysis of 32 complex traits in the Lifelines Cohort Study

Despite the recent explosive rise in number of genetic markers for complex disease traits identified in genome-wide association studies, there is still a large gap between the known heritability of these traits and the part explained by these markers. To gauge whether this 'heritability gap...

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Veröffentlicht in:	European journal of human genetics : EJHG Jg. 25; H. 7; S. 877 - 885
Hauptverfasser:	Nolte, Ilja M, van der Most, Peter J, Alizadeh, Behrooz Z, de Bakker, Paul IW, Boezen, H Marike, Bruinenberg, Marcel, Franke, Lude, van der Harst, Pim, Navis, Gerjan, Postma, Dirkje S, Rots, Marianne G, Stolk, Ronald P, Swertz, Morris A, Wolffenbuttel, Bruce HR, Wijmenga, Cisca, Snieder, Harold
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.06.2017
Schlagworte:	Bioinformatics Blood Cell Count Blood Pressure - genetics Clinical medicine Diabetes Disease Epidemiology Gene loci Genes, Dominant Genetic markers Genetic Predisposition to Disease Genetics Genome-Wide Association Study - methods Genome-Wide Association Study - standards Genomes Health risk assessment Heart Rate - genetics Heritability Humans Morbidity Phenotype Polymorphism, Single Nucleotide Quantitative Trait, Heritable Respiration - genetics Single-nucleotide polymorphism Studies Netherlands
ISSN:	1018-4813, 1476-5438, 1476-5438
Online-Zugang:	Volltext
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