Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile

This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment...

Full description

Saved in:

Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 29; no. 8; p. 1824
Main Authors:	Ferreira-Filho, Vital Cruvinel, Morais, Beatriz, Vieira, Bruno J. C., Waerenborgh, João Carlos, Carmezim, Maria João, Tóth, Csilla Noémi, Même, Sandra, Lacerda, Sara, Jaque, Daniel, Sousa, Célia T., Campello, Maria Paula Cabral, Pereira, Laura C. J.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 17.04.2024 MDPI
Subjects:	Biocompatibility Cancer therapies Chemical Sciences Coatings Contrast agents Contrast Media - chemistry Dextrans - chemistry Fever gadolinium Gadolinium - chemistry Gold Gold - chemistry gold nanoparticles Humans Hyperthermia Hyperthermia, Induced - methods iron oxides nanoparticles Magnetic Iron Oxide Nanoparticles - chemistry Magnetic properties Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - therapeutic use Nanomaterials Nanoparticles Particle Size Peptides Polyethylene glycol Polymers Spectrum analysis superparamagnetism Surface Properties Theranostic Nanomedicine Toxicity France iron oxides nanoparticles hyperthermia magnetic resonance imaging gold nanoparticles superparamagnetism gadolinium
ISSN:	1420-3049, 1420-3049
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.
AbstractList	This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (M[sub.R/P]) and co-precipitation at controlled pH (M[sub.pH]), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from M[sub.R/P] consist of approximately 11–13% of Fe present in magnetite, while samples obtained from M[sub.pH] have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SP[sub.pH]-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis. This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (M ) and co-precipitation at controlled pH (M ), were explored, including the assessment of the coating's influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from M consist of approximately 11-13% of Fe present in magnetite, while samples obtained from M have higher contents of 33-45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SP -Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis. This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction–precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating’s influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11–13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33–45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis. This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating's influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11-13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33-45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (MR/P) and co-precipitation at controlled pH (MpH), were explored, including the assessment of the coating's influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI). Parameters such as size, stability, morphology, and magnetic behavior were evaluated by a detailed characterization analysis. To assess their efficacy in imaging and therapy, relaxivity and hyperthermia experiments were performed, respectively. The results revealed that both synthetic methods lead to SPIONs with similar average size, 9 nm. Mössbauer spectroscopy indicated that samples obtained from MR/P consist of approximately 11-13% of Fe present in magnetite, while samples obtained from MpH have higher contents of 33-45%. Despite coating and functionalization, all samples exhibited superparamagnetic behavior at room temperature. Hyperthermia experiments showed increased SAR values with higher magnetic field intensity and frequency. Moreover, the relaxivity studies suggested potential dual T1/T2 contrast agent capabilities for the coated SPpH-Dx-Au-Gd sample, thus demonstrating its potential in cancer diagnosis.
Audience	Academic
Author	Lacerda, Sara Pereira, Laura C. J. Tóth, Csilla Noémi Carmezim, Maria João Morais, Beatriz Même, Sandra Ferreira-Filho, Vital Cruvinel Sousa, Célia T. Campello, Maria Paula Cabral Vieira, Bruno J. C. Waerenborgh, João Carlos Jaque, Daniel
Author_xml	– sequence: 1 givenname: Vital Cruvinel orcidid: 0009-0002-1493-5950 surname: Ferreira-Filho fullname: Ferreira-Filho, Vital Cruvinel – sequence: 2 givenname: Beatriz surname: Morais fullname: Morais, Beatriz – sequence: 3 givenname: Bruno J. C. orcidid: 0000-0002-6536-9875 surname: Vieira fullname: Vieira, Bruno J. C. – sequence: 4 givenname: João Carlos orcidid: 0000-0001-6171-4099 surname: Waerenborgh fullname: Waerenborgh, João Carlos – sequence: 5 givenname: Maria João orcidid: 0000-0002-0110-187X surname: Carmezim fullname: Carmezim, Maria João – sequence: 6 givenname: Csilla Noémi surname: Tóth fullname: Tóth, Csilla Noémi – sequence: 7 givenname: Sandra surname: Même fullname: Même, Sandra – sequence: 8 givenname: Sara orcidid: 0000-0003-3865-4379 surname: Lacerda fullname: Lacerda, Sara – sequence: 9 givenname: Daniel surname: Jaque fullname: Jaque, Daniel – sequence: 10 givenname: Célia T. surname: Sousa fullname: Sousa, Célia T. – sequence: 11 givenname: Maria Paula Cabral surname: Campello fullname: Campello, Maria Paula Cabral – sequence: 12 givenname: Laura C. J. orcidid: 0000-0002-8818-0039 surname: Pereira fullname: Pereira, Laura C. J.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/38675647$$D View this record in MEDLINE/PubMed https://hal.science/hal-04630978$$DView record in HAL
BookMark	eNp1klFv0zAQgC00xLbCD-AFReIFHjrOcRzbj1U1WKXChjaeLce5dK5Su9gJEv8ed-kQDCE_nHX-7tPpzufkxAePhLymcMGYgg-70KMde0ylAkllWT0jZ7QqYc6gUid_3E_JeUpbgJJWlL8gp0zWgteVOCNfV77rR_QWi9AVtzer6y_F7Rg7kxPLYAbnN0XwxWez8Tg4W9zEsMc4OEyF8W1xd4_R-JCOT53r8SV53pk-4atjnJFvHy_vllfz9fWn1XKxnltO6TCvec1N1cjOUGlrxnNzYEpWd1yCbVtgCKpFgUoqBi20jWGIFrBpGCqUHZuR1eRtg9nqfXQ7E3_qYJx-SIS40SY3anvUqkHOqZJNVaqqaVFKriohamE5V1wcXO8n173p_1JdLdb6kIOqZqCE_EEz-25i9zF8HzENeueSxb43HsOYdJ63yPaSQkbfPkG3YYw-T-WBAgAqeaYuJmpjcq_Od2GIxubT4s7ZvPHDVPVCKMa5FDnMyJujdmx22P5u-HGrGRATYGNIKWKnrRvyLoPPZtdrCvrwf_Q__ydX0ieVj_L_1_wCr5fHcA
CitedBy_id	crossref_primary_10_1134_S2635167624601736 crossref_primary_10_1021_acsaelm_5c00830 crossref_primary_10_1016_j_ceramint_2025_01_388 crossref_primary_10_1016_j_ccr_2024_216286 crossref_primary_10_3389_fnhum_2025_1489940 crossref_primary_10_1002_pat_70343 crossref_primary_10_1016_j_bbrc_2025_152542 crossref_primary_10_1016_j_matdes_2025_114269 crossref_primary_10_1007_s12032_025_02913_z crossref_primary_10_1002_adma_202507559 crossref_primary_10_1039_D5NR00608B
Cites_doi	10.1016/j.matchar.2013.09.002 10.1186/s11671-017-2084-y 10.1039/C1CS15248C 10.1021/bc900424u 10.1039/C5NJ00921A 10.1021/jp075133m 10.1016/j.mtcomm.2023.106819 10.1023/A:1012635124874 10.1093/biomet/46.1-2.77 10.1186/s12951-020-0580-1 10.3390/nano13010014 10.1016/j.addr.2020.06.025 10.1016/j.matlet.2005.09.030 10.1002/9781118503652 10.1007/s10948-020-05607-x 10.1088/0022-3735/7/7/012 10.1016/j.biopha.2022.112951 10.1088/1742-6596/2114/1/012037 10.1016/j.physe.2006.12.041 10.1016/j.jssc.2013.01.037 10.1002/smll.201201531 10.1155/2014/589479 10.2147/IJN.S214236 10.1002/admi.202202214 10.1155/2013/148578 10.3390/ma13030513 10.1016/j.partic.2010.01.003 10.1007/s13204-016-0542-y 10.1088/2053-1591/aa96e3 10.1007/s11051-011-0362-7 10.1186/s40199-015-0124-7 10.3322/caac.21763 10.1016/j.jmmm.2006.01.251 10.1155/2022/4326939 10.1039/D2NR00808D 10.1016/j.jmmm.2013.11.006 10.3390/ijms23095279 10.2147/IJN.S156528 10.1007/s13204-023-02803-8 10.1088/2043-6254/1/3/035001 10.1021/jp510656d 10.1021/acs.chemrev.8b00363 10.1007/s003300100908 10.3389/fphar.2022.797804 10.1016/j.jmmm.2012.06.045 10.1088/0953-8984/15/10/325 10.1186/s13244-021-01125-z 10.1016/j.ijpharm.2020.120097 10.1039/D0RA06215D 10.1016/j.jmmm.2022.169379 10.3390/nano9070943 10.1016/j.colsurfb.2016.09.021 10.1063/1.478435 10.1186/s12989-022-00465-y 10.1049/mnl.2019.0811 10.3390/cryst13030472 10.7150/ntno.78807 10.1021/acs.nanolett.6b00599 10.1023/A:1012603603203 10.1002/adma.200802366 10.1021/nn500188y 10.1080/14686996.2018.1517587 10.1021/acs.bioconjchem.6b00102 10.3390/ma14205948 10.1007/s42452-020-03646-6 10.1021/jp500816u 10.2967/jnumed.116.181362 10.1088/0957-4484/23/21/215602 10.7150/thno.23789 10.1002/adma.201804567
ContentType	Journal Article
Copyright	COPYRIGHT 2024 MDPI AG 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. licence_http://creativecommons.org/publicdomain/zero
Copyright_xml	– notice: COPYRIGHT 2024 MDPI AG – notice: 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: licence_http://creativecommons.org/publicdomain/zero
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S M1P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 1XC VOOES DOA
DOI	10.3390/molecules29081824
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Proquest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Hyper Article en Ligne (HAL) Hyper Article en Ligne (HAL) (Open Access) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE Publicly Available Content Database MEDLINE - Academic CrossRef
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Chemistry
EISSN	1420-3049
ExternalDocumentID	oai_doaj_org_article_9be55198b4294bde885947767c55957f oai:HAL:hal-04630978v1 A793558779 38675647 10_3390_molecules29081824
Genre	Journal Article
GeographicLocations	France
GeographicLocations_xml	– name: France
GroupedDBID	--- 0R~ 123 2WC 53G 5VS 7X7 88E 8FE 8FG 8FH 8FI 8FJ A8Z AADQD AAFWJ AAHBH AAYXX ABDBF ABUWG ACGFO ACIWK ACPRK ACUHS AEGXH AENEX AFFHD AFKRA AFPKN AFRAH AFZYC AIAGR ALMA_UNASSIGNED_HOLDINGS BENPR BPHCQ BVXVI CCPQU CITATION CS3 D1I DIK DU5 E3Z EBD EMOBN ESTFP ESX FYUFA GROUPED_DOAJ GX1 HH5 HMCUK HYE HZ~ I09 IAO IHR ITC KQ8 LK8 M1P MODMG O-U O9- OK1 P2P PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO RPM SV3 TR2 TUS UKHRP ~8M ALIPV CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK AZQEC DWQXO K9. PKEHL PQEST PQUKI PRINS 7X8 PUEGO 1XC VOOES
ID	FETCH-LOGICAL-c511t-6565a4b8fa18c6350020a236f580cdd03e09de7e98930d0dba3eec0ebb3e9e8f3
IEDL.DBID	7X7
ISICitedReferencesCount	17
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001220422700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1420-3049
IngestDate	Tue Oct 14 19:09:41 EDT 2025 Wed Nov 26 07:12:56 EST 2025 Thu Oct 02 10:05:31 EDT 2025 Sat Nov 29 14:28:35 EST 2025 Tue Nov 04 18:22:34 EST 2025 Mon Jul 21 05:45:48 EDT 2025 Sat Nov 29 07:16:26 EST 2025 Tue Nov 18 21:08:09 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	8
Keywords	iron oxides nanoparticles hyperthermia magnetic resonance imaging gold nanoparticles superparamagnetism gadolinium
Language	English
License	licence_http://creativecommons.org/publicdomain/zero/: http://creativecommons.org/publicdomain/zero
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c511t-6565a4b8fa18c6350020a236f580cdd03e09de7e98930d0dba3eec0ebb3e9e8f3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC11052394
ORCID	0000-0001-6171-4099 0000-0003-3865-4379 0009-0002-1493-5950 0000-0002-6536-9875 0000-0002-0110-187X 0000-0002-8818-0039 0000-0002-3765-0889
OpenAccessLink	https://www.proquest.com/docview/3047000185?pq-origsite=%requestingapplication%
PMID	38675647
PQID	3047000185
PQPubID	2032355
ParticipantIDs	doaj_primary_oai_doaj_org_article_9be55198b4294bde885947767c55957f hal_primary_oai_HAL_hal_04630978v1 proquest_miscellaneous_3047947210 proquest_journals_3047000185 gale_infotracacademiconefile_A793558779 pubmed_primary_38675647 crossref_citationtrail_10_3390_molecules29081824 crossref_primary_10_3390_molecules29081824
PublicationCentury	2000
PublicationDate	2024-Apr-17
PublicationDateYYYYMMDD	2024-04-17
PublicationDate_xml	– month: 04 year: 2024 text: 2024-Apr-17 day: 17
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland – name: Basel
PublicationTitle	Molecules (Basel, Switzerland)
PublicationTitleAlternate	Molecules
PublicationYear	2024
Publisher	MDPI AG MDPI
Publisher_xml	– name: MDPI AG – name: MDPI
References	Blasiak (ref_64) 2013; 2013 Cabrera (ref_63) 2022; 14 Maleki (ref_45) 2012; 324 Thapa (ref_69) 2017; 12 Thakor (ref_5) 2016; 57 ref_14 Na (ref_67) 2009; 21 Devi (ref_22) 2020; 33 Paterson (ref_1) 2022; 4 ref_10 Bae (ref_68) 2010; 21 Predoi (ref_56) 2003; 15 Samrot (ref_49) 2019; 14 Osborne (ref_44) 2012; 23 Wahsner (ref_70) 2019; 119 Dorsey (ref_32) 2013; 2 ref_18 ref_17 ref_15 Farhana (ref_26) 2022; 2022 Ngo (ref_37) 2010; 1 Nurdin (ref_42) 2014; 2014 Silva (ref_19) 2023; 7 Singh (ref_58) 2013; 200 Bakhtari (ref_40) 2020; 14 Yang (ref_13) 2023; 13 ref_21 Girardet (ref_76) 2023; 36 Silva (ref_16) 2016; 27 Khalkhali (ref_39) 2015; 23 Chen (ref_43) 2020; 15 Murad (ref_54) 1998; 117 Uvarov (ref_25) 2013; 85 Tantra (ref_51) 2010; 8 Cheng (ref_73) 2014; 8 ref_71 Maguire (ref_46) 2018; 19 Singh (ref_28) 2017; 55 Zhang (ref_77) 2015; 119 Soetaert (ref_7) 2020; 163–164 ref_35 Abed (ref_3) 2022; 13 Sailsman (ref_36) 2014; 118 Silva (ref_50) 2016; 28 Vandenberghe (ref_57) 2000; 126 Lee (ref_48) 2012; 41 Ferreira (ref_33) 2020; 10 Wu (ref_6) 2022; 19 Long (ref_53) 1987; Volume 2 Roch (ref_74) 1999; 110 Roca (ref_55) 2007; 111 Bhattacharya (ref_34) 2011; 13 Ta (ref_75) 2017; 4 Samrot (ref_24) 2017; 7 Liu (ref_11) 2013; 9 Mahadevan (ref_30) 2007; 39 Unterweger (ref_41) 2018; 13 (ref_23) 2020; 2 Zhou (ref_65) 2019; 31 Gaeta (ref_9) 2021; 12 Yousuf (ref_38) 2015; 39 ref_47 Holbrook (ref_72) 2016; 16 Dizaji (ref_12) 2016; 44 Deatsch (ref_62) 2014; 354 Freitas (ref_60) 2023; 10 Bala (ref_31) 2006; 60 Zhang (ref_78) 2018; 8 Aziz (ref_8) 2020; 8 Saraiva (ref_20) 2021; 593 Hesse (ref_79) 1974; 7 Siegel (ref_2) 2023; 73 (ref_29) 2021; 2114 Xiang (ref_66) 2001; 11 ref_4 Battisha (ref_27) 2006; 306 Box (ref_59) 1959; 46 Wang (ref_52) 2016; 148 Liu (ref_61) 2022; 555
References_xml	– volume: 85 start-page: 111 year: 2013 ident: ref_25 article-title: Metrological characterization of X-ray diffraction methods at different acquisition geometries for determination of crystallite size in nano-scale materials publication-title: Mater. Charact. doi: 10.1016/j.matchar.2013.09.002 – volume: 12 start-page: 312 year: 2017 ident: ref_69 article-title: Enhanced MRI T 2 Relaxivity in Contrast-Probed Anchor-Free PEGylated Iron Oxide Nanoparticles publication-title: Nanoscale Res. Lett. doi: 10.1186/s11671-017-2084-y – volume: 41 start-page: 2575 year: 2012 ident: ref_48 article-title: Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents publication-title: Chem. Soc. Rev. doi: 10.1039/C1CS15248C – volume: 21 start-page: 505 year: 2010 ident: ref_68 article-title: Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual Contrast T1- and T2-Weighted Magnetic Resonance Imaging publication-title: Bioconj. Chem. doi: 10.1021/bc900424u – volume: 39 start-page: 7879 year: 2015 ident: ref_38 article-title: Loading of chromenones on superparamagnetic iron oxide-modified dextran core–shell nanoparticles: Openness to bind to β-cyclodextrin and DNA publication-title: New J. Chem. doi: 10.1039/C5NJ00921A – volume: 111 start-page: 18577 year: 2007 ident: ref_55 article-title: Uniform, and water stable magnetite nanoparticles with diameters around the monodomain–multidomain limit publication-title: J. Phys. Chem. C doi: 10.1021/jp075133m – volume: 36 start-page: 106819 year: 2023 ident: ref_76 article-title: SPIONs magnetic nanoparticles for MRI applications: Microwave synthesis and physicochemical, magnetic and biological characterizations publication-title: Mater. Today Commun. doi: 10.1016/j.mtcomm.2023.106819 – volume: 117 start-page: 39 year: 1998 ident: ref_54 article-title: Clays and clay minerals: What can Mössbauer spectroscopy do to help understand them? publication-title: Hyperfine Interact. doi: 10.1023/A:1012635124874 – volume: 2 start-page: 280 year: 2013 ident: ref_32 article-title: Gold nanoparticles in radiation research: Potential applications for imaging and radiosensitization publication-title: Transl. Cancer Res. – volume: 46 start-page: 77 year: 1959 ident: ref_59 article-title: Design of experiments in non-linear situations publication-title: Biometrika doi: 10.1093/biomet/46.1-2.77 – ident: ref_10 doi: 10.1186/s12951-020-0580-1 – volume: 4 start-page: 85 year: 2022 ident: ref_1 article-title: Incident cardiovascular disease among adults with cancer: A population-based cohort study publication-title: J. Am. Coll. Cardiol. Cardio Oncol. – ident: ref_21 doi: 10.3390/nano13010014 – volume: 28 start-page: 731 year: 2016 ident: ref_50 article-title: Studies of the Colloidal Properties of Superparamagnetic Iron Oxide Nanoparticles Functionalized with Platinum Complexes in Aqueous and PBS Buffer Media publication-title: J. Braz. Chem. Soc. – volume: Volume 2 start-page: 89 year: 1987 ident: ref_53 article-title: Mössbauer Effect Studies of Microcrystalline Materials publication-title: Mössbauer Spectroscopy Applied to Inorganic Chemistry – volume: 163–164 start-page: 65 year: 2020 ident: ref_7 article-title: Cancer therapy with iron oxide nanoparticles: Agents of thermal and immune therapies publication-title: Adv. Drug Delivery Rev. doi: 10.1016/j.addr.2020.06.025 – volume: 60 start-page: 494 year: 2006 ident: ref_31 article-title: Controlling the particle size of nanocrystalline titania via a thermal dissociation of substrates with ammonium chloride publication-title: Mater. Lett. doi: 10.1016/j.matlet.2005.09.030 – ident: ref_71 doi: 10.1002/9781118503652 – volume: 33 start-page: 3893 year: 2020 ident: ref_22 article-title: Role of citric acid/glycine-reinforced nanometal oxide for the enhancement of physio-chemical specifications in catalytic properties publication-title: J. Supercond. Nov. Magn. doi: 10.1007/s10948-020-05607-x – volume: 7 start-page: 526 year: 1974 ident: ref_79 article-title: Model independent evaluation of overlapped Mossbauer spectra publication-title: J. Phys. E doi: 10.1088/0022-3735/7/7/012 – ident: ref_4 doi: 10.1016/j.biopha.2022.112951 – volume: 2114 start-page: 012037 year: 2021 ident: ref_29 article-title: Synthesis and Characterization of Dextran coated Iron Oxide Nanoparticles as a T1 Contrast Agent publication-title: J. Phys. Conf. Ser. doi: 10.1088/1742-6596/2114/1/012037 – volume: 39 start-page: 20 year: 2007 ident: ref_30 article-title: X-ray diffraction-based characterization of magnetite nanoparticles in presence of goethite and correlation with magnetic properties publication-title: Phys. E Low-Dimens. Syst. Nanostructures doi: 10.1016/j.physe.2006.12.041 – volume: 200 start-page: 150 year: 2013 ident: ref_58 article-title: Vapour phase approach for iron oxide nanoparticle synthesis from solid precursors publication-title: J. Solid. State Chem. doi: 10.1016/j.jssc.2013.01.037 – volume: 9 start-page: 1533 year: 2013 ident: ref_11 article-title: Applications and potential toxicity of magnetic iron oxide nanoparticles publication-title: Small doi: 10.1002/smll.201201531 – volume: 2014 start-page: 589479 year: 2014 ident: ref_42 article-title: Effect of nitric acid concentrations on synthesis and stability of maghemite nanoparticles suspension publication-title: Sci. World J. doi: 10.1155/2014/589479 – volume: 14 start-page: 8105 year: 2019 ident: ref_49 article-title: Surface-engineered super-paramagnetic iron oxide nanoparticles for chromium removal publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S214236 – volume: 10 start-page: 2202214 year: 2023 ident: ref_60 article-title: Key parameters in phototherapy with gold nanorods using continuous near infrared radiation publication-title: Adv. Mater. Interfaces doi: 10.1002/admi.202202214 – volume: 2013 start-page: 148578 year: 2013 ident: ref_64 article-title: Applications of nanoparticles for MRI cancer diagnosis and therapy publication-title: J. Nanomater. doi: 10.1155/2013/148578 – ident: ref_17 doi: 10.3390/ma13030513 – volume: 8 start-page: 279 year: 2010 ident: ref_51 article-title: Effect of Nanoparticle Concentration on Zeta-Potential Measurement Results and Reproducibility publication-title: Particuology doi: 10.1016/j.partic.2010.01.003 – volume: 8 start-page: 21 year: 2020 ident: ref_8 article-title: Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Preparation and Recent Applications publication-title: J. Nanotech. Adv. Mat. – volume: 7 start-page: 17 year: 2017 ident: ref_24 article-title: A study on the effect of chemically synthesized magnetite nanoparticles on earthworm: Eudrilus eugeniae publication-title: Appl. Nanosci. doi: 10.1007/s13204-016-0542-y – volume: 4 start-page: 116105 year: 2017 ident: ref_75 article-title: Effects of magnetic field strength and particle aggregation on relaxivity of ultra-small dual contrast iron oxide nanoparticles publication-title: Mater. Res. Express doi: 10.1088/2053-1591/aa96e3 – volume: 13 start-page: 4173 year: 2011 ident: ref_34 article-title: Synthesis, characterization, and in vitro biological evaluation of highly stable diversely functionalized superparamagnetic iron oxide nanoparticles publication-title: J. Nanopart. Res. doi: 10.1007/s11051-011-0362-7 – volume: 23 start-page: 45 year: 2015 ident: ref_39 article-title: The impact of polymer coatings on magnetite nanoparticles performance as MRI contrast agents: A comparative study publication-title: DARU J. Pharm. Sci. doi: 10.1186/s40199-015-0124-7 – volume: 73 start-page: 17 year: 2023 ident: ref_2 article-title: Cancer statistics, 2023 publication-title: CA Cancer J. Clin. doi: 10.3322/caac.21763 – volume: 306 start-page: 211 year: 2006 ident: ref_27 article-title: Synthesis of Fe2O3 concentrations and sintering temperature on FTIR and magnetic susceptibility measured from 4 to 300 K of monolith silica gel prepared by sol–gel technique publication-title: J. Magn. Magn. Mater. doi: 10.1016/j.jmmm.2006.01.251 – volume: 2022 start-page: 4326939 year: 2022 ident: ref_26 article-title: Utilization of superparamagnetic iron oxide nanoparticles (SPIONs) impregnated activated carbon for removal of hexavalent chromium publication-title: J. Nanomater. doi: 10.1155/2022/4326939 – volume: 14 start-page: 8789 year: 2022 ident: ref_63 article-title: Superparamagnetic-blocked state transition under alternating magnetic fields: Towards determining the magnetic anisotropy in magnetic suspensions publication-title: Nanoscale doi: 10.1039/D2NR00808D – volume: 354 start-page: 163 year: 2014 ident: ref_62 article-title: Heating efficiency in magnetic nanoparticle hyperthermia publication-title: J. Magn. Magn. Mat. doi: 10.1016/j.jmmm.2013.11.006 – ident: ref_18 doi: 10.3390/ijms23095279 – volume: 13 start-page: 1899 year: 2018 ident: ref_41 article-title: Dextran-coated superparamagnetic iron oxide nanoparticles for magnetic resonance imaging: Evaluation of size-dependent imaging properties, storage stability and safety publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S156528 – volume: 13 start-page: 5489 year: 2023 ident: ref_13 article-title: Nanoenzyme-Based Electrodes in Biomolecular Screening and Analysis publication-title: Appl. Nanosci. doi: 10.1007/s13204-023-02803-8 – volume: 44 start-page: 1109 year: 2016 ident: ref_12 article-title: Silver or gold deposition onto magnetite nanoparticles by using plant extracts as reducing and stabilizing agents publication-title: Artifi. Cells Nanomed. Biotechnol. – volume: 1 start-page: 035001 year: 2010 ident: ref_37 article-title: Facile and solvent-free routes for the synthesis of size-controllable Fe3O4 nanoparticles publication-title: Adv. Nat. Sci. Nanosci. Nanotechnol. doi: 10.1088/2043-6254/1/3/035001 – volume: 119 start-page: 5080 year: 2015 ident: ref_77 article-title: Prototropic Exchange Governs T1 and T2 Relaxivities of a Potential MRI Contrast Agent Nanozeolite Gd−LTL with a High pH Responsiveness publication-title: J. Phys. Chem. C doi: 10.1021/jp510656d – volume: 119 start-page: 957 year: 2019 ident: ref_70 article-title: Chemistry of MRI contrast agents: Current challenges and new frontiers publication-title: Chem. Rev. doi: 10.1021/acs.chemrev.8b00363 – volume: 11 start-page: 2319 year: 2001 ident: ref_66 article-title: Superparamagnetic iron oxide contrast agents: Physicochemical characteristics and applications in MR imaging publication-title: Eur. Radiol. doi: 10.1007/s003300100908 – volume: 13 start-page: 797804 year: 2022 ident: ref_3 article-title: Cutting-Edge Applications of Nanomaterials in Biomedical Sciences publication-title: Front. Pharmacol. doi: 10.3389/fphar.2022.797804 – volume: 324 start-page: 3997 year: 2012 ident: ref_45 article-title: Size-controlled synthesis of superparamagnetic iron oxide nanoparticles and their surface coating by gold for biomedical applications publication-title: J. Magn. Magn. Mat. doi: 10.1016/j.jmmm.2012.06.045 – volume: 15 start-page: 1797 year: 2003 ident: ref_56 article-title: Magnetic relaxation phenomena and inter-particle interactions in nanosized γ-Fe2O3 systems publication-title: J. Phys. Condens. Matter doi: 10.1088/0953-8984/15/10/325 – volume: 12 start-page: 179 year: 2021 ident: ref_9 article-title: Magnetism of materials: Theory and practice in magnetic resonance imaging publication-title: Insights Imaging doi: 10.1186/s13244-021-01125-z – volume: 593 start-page: 120097 year: 2021 ident: ref_20 article-title: 3D-printed platform multi-loaded with bioactive, magnetic nanoparticles and an antibiotic for re-growing bone tissue publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2020.120097 – volume: 10 start-page: 38490 year: 2020 ident: ref_33 article-title: Superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with lipase Candida antarctica A for biodiesel synthesis publication-title: RSC Adv. doi: 10.1039/D0RA06215D – volume: 555 start-page: 169379 year: 2022 ident: ref_61 article-title: The “field or frequency” dilemma in magnetic hyperthermia: The case of ZnMn ferrite nanoparticles publication-title: J. Magn. Magn. Mat. doi: 10.1016/j.jmmm.2022.169379 – ident: ref_14 doi: 10.3390/nano9070943 – volume: 148 start-page: 541 year: 2016 ident: ref_52 article-title: Zeta-Potential Data Reliability of Gold Nanoparticle Biomolecular Conjugates and Its Application in Sensitive Quantification of Surface Absorbed Protein publication-title: Colloids Surf. B Biointerfaces doi: 10.1016/j.colsurfb.2016.09.021 – volume: 110 start-page: 5403 year: 1999 ident: ref_74 article-title: Theory of proton relaxation induced by superparamagnetic particles publication-title: J. Chem. Phys. doi: 10.1063/1.478435 – volume: 19 start-page: 24 year: 2022 ident: ref_6 article-title: Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles publication-title: Part. Fibre Toxicol. doi: 10.1186/s12989-022-00465-y – volume: 15 start-page: 645 year: 2020 ident: ref_43 article-title: Synthesis of iron-oxide magnetic nanoparticles coated with dextran of varied molecular mass using a facile ball-milling method publication-title: Micro Nano Lett. doi: 10.1049/mnl.2019.0811 – ident: ref_35 doi: 10.3390/cryst13030472 – volume: 7 start-page: 22 year: 2023 ident: ref_19 article-title: Image-guided nanodelivery of Pt (IV) prodrugs to GRP-receptor positive tumors publication-title: Nanotheranostics doi: 10.7150/ntno.78807 – volume: 16 start-page: 3202 year: 2016 ident: ref_72 article-title: Gd(III)-Dithiolane Gold Nanoparticles for T1-Weighted Magnetic Resonance Imaging of the Pancreas publication-title: Nano Lett. doi: 10.1021/acs.nanolett.6b00599 – volume: 126 start-page: 247 year: 2000 ident: ref_57 article-title: Mössbauer characterization of iron oxides and (oxy) hydroxides: The present state of the art publication-title: Hyperfine Interact. doi: 10.1023/A:1012603603203 – volume: 14 start-page: 161 year: 2020 ident: ref_40 article-title: Toxic Effects of Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles on Mouse Embryo Development, Genes Expression of Antioxidant Enzymes and Apoptosis, and Ultrastructure of Sperm, Oocytes and Granulosa Cells publication-title: Int. J. Fertil. Steril. – volume: 21 start-page: 2133 year: 2009 ident: ref_67 article-title: Inorganic nanoparticles for MRI contrast agents publication-title: Adv. Mater. doi: 10.1002/adma.200802366 – volume: 8 start-page: 9884 year: 2014 ident: ref_73 article-title: Hybrid Nanotrimers for Dual T1 and T2-Weighted Magnetic Resonance Imaging publication-title: ACS Nano doi: 10.1021/nn500188y – volume: 55 start-page: 722 year: 2017 ident: ref_28 article-title: Synthesis, characterization, and electrocatalytic ability of γ-Fe2O3 nanoparticles for sensing acetaminophen publication-title: Indian J. Pure Appl. Phys. – volume: 19 start-page: 732 year: 2018 ident: ref_46 article-title: Characterisation of particles in solution–a perspective on light scattering and comparative technologies publication-title: Sci. Technol. Adv. Mater. doi: 10.1080/14686996.2018.1517587 – volume: 27 start-page: 1153 year: 2016 ident: ref_16 article-title: Interrogating the Role of Receptor-Mediated Mechanisms: Biological Fate of Peptide-Functionalized Radiolabeled Gold Nanoparticles in Tumor Mice publication-title: Bioconjugate Chem. doi: 10.1021/acs.bioconjchem.6b00102 – ident: ref_15 – ident: ref_47 doi: 10.3390/ma14205948 – volume: 2 start-page: 1844 year: 2020 ident: ref_23 article-title: Light scattering and plasmonic response of Au–Fe3O4 nanoparticles publication-title: SN Appl. Sci. doi: 10.1007/s42452-020-03646-6 – volume: 118 start-page: 8691 year: 2014 ident: ref_36 article-title: Large-Scale Synthesis of Colloidal Fe3O4 Nanoparticles Exhibiting High Heating Efficiency in Magnetic Hyperthermia publication-title: J. Phys. Chem. C doi: 10.1021/jp500816u – volume: 57 start-page: 1833 year: 2016 ident: ref_5 article-title: Clinically Approved Nanoparticle Imaging Agents publication-title: J. Nucl. Med. doi: 10.2967/jnumed.116.181362 – volume: 23 start-page: 215602 year: 2012 ident: ref_44 article-title: Rapid microwave-assisted synthesis of dextran-coated iron oxide nanoparticles for magnetic resonance imaging publication-title: Nanotechnology doi: 10.1088/0957-4484/23/21/215602 – volume: 8 start-page: 2521 year: 2018 ident: ref_78 article-title: Surface impact on nanoparticle-based magnetic resonance imaging contrast agents publication-title: Theranostics doi: 10.7150/thno.23789 – volume: 31 start-page: 1804567 year: 2019 ident: ref_65 article-title: Structure–relaxivity relationships of magnetic nanoparticles for magnetic resonance imaging publication-title: Adv. Mater. doi: 10.1002/adma.201804567
SSID	ssj0021415
Score	2.4946847
Snippet	This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two...
SourceID	doaj hal proquest gale pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	1824
SubjectTerms	Biocompatibility Cancer therapies Chemical Sciences Coatings Contrast agents Contrast Media - chemistry Dextrans - chemistry Fever gadolinium Gadolinium - chemistry Gold Gold - chemistry gold nanoparticles Humans Hyperthermia Hyperthermia, Induced - methods iron oxides nanoparticles Magnetic Iron Oxide Nanoparticles - chemistry Magnetic properties Magnetic resonance imaging Magnetic Resonance Imaging - methods Magnetite Nanoparticles - chemistry Magnetite Nanoparticles - therapeutic use Nanomaterials Nanoparticles Particle Size Peptides Polyethylene glycol Polymers Spectrum analysis superparamagnetism Surface Properties Theranostic Nanomedicine Toxicity
SummonAdditionalLinks	– databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9UwFD_oEPRl-G11jiiCIJT1Nk2TPF4vjg3muLIJewtJmuhgtuN-7O_3nKYtDlFffE3SNjk5Oed3muR3AN7VvoyVa1xeNqXIK7SAuY3K5bVwziqPHitR5p_I01N1caGXv6T6ojNhiR44Ce5Au4BOXSuHhhNfGpQSuiIKGo9YWMhI1reQegymhlBrhn4p7WFyDOoPfqRUs2FdaqJwK6tbXqgn659M8t3vdCLyT3CzdzuHD2F3wItsnvr5CO6E9jHcX4xp2p7Al-MxzQjrIjtbom1kZ9tVtFiw6CydamZdyz7bby3dV2RL-vu-IhpVZtuGndP9q7ZbD1VE0_QUvh5-Ol8c5UOehNwjXNqgXGthK6einSmPAIIgoC15HYUqfNMUPBS6CTJoxCZFUzTO8hB8EZzjQQcV-TPYabs2vACmamkJRGAfQxV4Y4XAhjWPwUtlucqgGOVm_EAiTrksrgwGEyRq85uoM_gwPXKdGDT-1vgjTcbUkMiv-wJUCTOohPmXSmTwnqbS0BLFznk73DTAIZIUzVz2pPJS6gze4mzf-trR_MRQGTGp0R2Xm1kGe6MymGGBrw3tVhI-ViKDN1M1Tj3tt9g2dNvUBjuGQXUGz5MSTZ_iKGlRV_Ll_xjwK3hQItaiTa6Z3IOdzWobXsM9f7O5XK_2-5XxE8ltEP4 priority: 102 providerName: Directory of Open Access Journals
Title	Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile
URI	https://www.ncbi.nlm.nih.gov/pubmed/38675647 https://www.proquest.com/docview/3047000185 https://www.proquest.com/docview/3047947210 https://hal.science/hal-04630978 https://doaj.org/article/9be55198b4294bde885947767c55957f
Volume	29
WOSCitedRecordID	wos001220422700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: DOA dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1420-3049 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0021415 issn: 1420-3049 databaseCode: PIMPY dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3da9RAEB9sK-iL3x_ReqwiCEJoLpvNbp7kerS00B7RVjifwn6lCprU5K5_vzNJLqWIffHlIJvNZbMzO_Ob_fgNwPvUxmVinAljF4swQQsY6lKZMBXGaGXRY_WU-SdysVDLZZYPE27tsK1yYxM7Q-1qS3Pke7Q8RIBEiU-Xv0PKGkWrq0MKjS3YobTZpOdyeR1wTdE79SuZHEP7vV99wlnfxhkRucXJDV_UUfaPhnnrO-2L_Bfo7JzP4cP_bfYjeDDATjbr9eQx3PHVE7g332R7ewqfjzfZSlhdsrMcTSw7WzelxoJ5rWlzNKsrdqovKjr2yHKaxG-IjZXpyrFzOsZV1e1wi9iensHXw4Pz-VE4pFsILaKuFYonFToxqtRTZRGHEJLUMU9LoSLrXMR9lDkvfYYQJ3KRM5p7byNvDPeZVyV_DttVXfmXwFQqNWERbKNPPHdaCKyY8tJbqTRXAUSbji_swEVOKTF-FhiTkKyKv2QVwMfxkcueiOO2yvskzbEicWh3BXVzUQxDssiMR7iYKYMuGdXVKyWyhMiNLEZZQpYBfCBdKGikY-OsHg4s4CdSLxYz2XHTS5kF8A7V5cbbjmYnBZURIRsdlbmaBrC70ZBisBNtca0eAbwdb6PoadlGV75e93WwYRibB_Ci18LxVRx7WqSJfHX7n7-G-zGCMVoFm8pd2F41a_8G7tqr1Y-2mXSDpvtVE9jZP1jkXybd3ARe5cen-bc_2jAlBA
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD7aBtJ44Q4LDDAIhIQULY2T2HlAqBSmVuuqohWpb8Z2nDEJkpG2Q_wpfiPn5NJpQuxtD7w6TuLYn88lx-c7AC8TG-aRyYwfZmHsRygBfZ1L4yexMVpa1FgNZf5YTCZyPk-nG_C7y4WhY5WdTKwFdVZa-ke-R-EhMkhk_O70h09Voyi62pXQaGBx4H79RJdt8Xb0Adf3VRjuf5wNhn5bVcC3aFwscRRJrCMjc92TFtUtGUw65Ekey8BmWcBdkGZOuBQ1eZAFmdHcORs4Y7hLncw5PncTrqEcF-Tsifm5g9dDbdhETjlPg73vTYFbtwhTIo4Lowu6ry4RsFYEm1_pHOa_jNxa2e3f-t-m6TbcbM1q1m_2wR3YcMVd2B501ezuwadRV42FlTk7mqIKYUerKtfYMCg1Hf5mZcEO9XFBaZ1sSkGKithmmS4yNqM0taJctJeIzeo-fL6SL3oAW0VZuB1gMhGabC0co4scz3QcY8eE584Kqbn0IOgWWtmWa51KfnxT6HMRNtRf2PDgzfqW04Zo5LLO7wk9647EEV43lNWxakWOSo1DcziVBqGK29FJGacRkTdZ9CJjkXvwmrCnSJLh4KxuEzLwE2kWVV_U3PtCpB68QHheeNuwP1bURoRzlAp01vNgt0OkauXgQp3D0YPn68u49BSW0oUrV00fHFjYCzx42KB-_SqOMx0nkXh0-cOfwfZwdjhW49Hk4DHcCNHwpIhfT-zC1rJauSdw3Z4tTxbV03rDMvhy1dD_A2fcfgY
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB61WwRceD8CBQwCISFFm7XzcA4ILVtWXXW7CmqRysnYjlOQICn7KOKv8euY2TxQheitB66Okzj255nPGfsbgOex5UVocuPznEd-iBbQ14U0fhwZo6VFj1VL5k-T2UweHaXZBvxqz8LQtsrWJq4NdV5Z-kfep_AQERIZ9YtmW0S2M35z8t2nDFIUaW3TadQQ2XM_f-DybfF6soNj_YLz8bvD0a7fZBjwLRKNJbYojnRoZKEH0qLrJfKkuYiLSAY2zwPhgjR3iUvRqwd5kBstnLOBM0a41MlC4HM3YQspech7sJVN9rOP3XJvgL6xjqMKkQb9b3W6W7fgKcnI8fCMJ1wnDOjcwuZn2pX5L8q7dn3j6_9zp92Aaw3hZsN6htyEDVfegiujNs_dbXg_afO0sKpgBxk6F3awmhcaC0aVpm3hrCrZvj4u6cAnyyh8MScdWqbLnB3SAbayWjSXSOfqDny4kC-6C72yKt19YDJONLEwbKMLnch1FGHFWBTOJlIL6UHQDrqyjQo7JQP5qnA1RjhRf-HEg1fdLSe1BMl5ld8SkrqKpB6-Lqjmx6oxRio1DolyKg2SEZyoTsooDUnWyeL6MkoKD14SDhXZOGyc1c1RDfxE6kU1TNaq_EmSevAMoXrmbbvDqaIykqKjQ0KnAw-2W3SqxkIu1B9oevC0u4xDTwErXbpqVdfBhvFB4MG9egZ0rxLY01EcJg_Of_gTuIyIV9PJbO8hXOXISCkUOEi2obecr9wjuGRPl18W88fN7GXw6aKx_xu3OohV
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Influence+of+SPION+Surface+Coating+on+Magnetic+Properties+and+Theranostic+Profile&rft.jtitle=Molecules+%28Basel%2C+Switzerland%29&rft.au=Ferreira-Filho%2C+Vital+Cruvinel&rft.au=Morais%2C+Beatriz&rft.au=Vieira%2C+Bruno+J.+C.&rft.au=Waerenborgh%2C+Jo%C3%A3o+Carlos&rft.date=2024-04-17&rft.issn=1420-3049&rft.eissn=1420-3049&rft.volume=29&rft.issue=8&rft.spage=1824&rft_id=info:doi/10.3390%2Fmolecules29081824&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_molecules29081824
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1420-3049&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1420-3049&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1420-3049&client=summon