Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection

Differentiating acute bacterial infection from other causes of lower respiratory tract illness is challenging. In this trial, procalcitonin was investigated as a point-of-care test to aid in determining whether antibiotics were needed in the treatment of these illnesses.

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Bibliographic Details
Published in:The New England journal of medicine Vol. 379; no. 3; pp. 236 - 249
Main Authors: Huang, David T, Yealy, Donald M, Filbin, Michael R, Brown, Aaron M, Chang, Chung-Chou H, Doi, Yohei, Donnino, Michael W, Fine, Jonathan, Fine, Michael J, Fischer, Michelle A, Holst, John M, Hou, Peter C, Kellum, John A, Khan, Feras, Kurz, Michael C, Lotfipour, Shahram, LoVecchio, Frank, Peck-Palmer, Octavia M, Pike, Francis, Prunty, Heather, Sherwin, Robert L, Southerland, Lauren, Terndrup, Thomas, Weissfeld, Lisa A, Yabes, Jonathan, Angus, Derek C
Format: Journal Article
Language:English
Published: United States Massachusetts Medical Society 19.07.2018
Subjects:
Adult
Aged
Anti-Bacterial Agents - therapeutic use
Antibiotics
Bacterial Infections - blood
Bacterial Infections - diagnosis
Bacterial Infections - drug therapy
Biomarkers - blood
Calcitonin - blood
Chronic obstructive pulmonary disease
Emergency medical care
Emergency Service, Hospital
Emergency services
FDA approval
Female
Guideline Adherence
Hospitalists
Hospitals
Humans
Illnesses
Inappropriate Prescribing - prevention & control
Inappropriate Prescribing - statistics & numerical data
Infections
Male
Medicine
Middle Aged
Patients
Pneumonia
Pneumonia - drug therapy
Practice Guidelines as Topic
Practice Patterns, Physicians' - statistics & numerical data
Procalcitonin
Respiratory tract diseases
Respiratory tract infection
Respiratory Tract Infections - blood
Respiratory Tract Infections - drug therapy
Viral infections
United States > US
Detroit Michigan
Pittsburgh Pennsylvania
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Description
Summary:Differentiating acute bacterial infection from other causes of lower respiratory tract illness is challenging. In this trial, procalcitonin was investigated as a point-of-care test to aid in determining whether antibiotics were needed in the treatment of these illnesses.
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1802670