Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER s...

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Vydáno v:	International journal of molecular sciences Ročník 18; číslo 2; s. 382
Hlavní autoři:	Ariyasu, Daisuke, Yoshida, Hiderou, Hasegawa, Yukihiro
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland MDPI AG 11.02.2017 MDPI
Témata:	Animals Diabetes Disease Models, Animal Endocrine System Diseases - diagnosis Endocrine System Diseases - etiology Endocrine System Diseases - metabolism Endocrine System Diseases - therapy Endoplasmic reticulum Endoplasmic Reticulum Stress Humans Mammals Review Signal Transduction Unfolded Protein Response endocrine disorder old astrocyte specifically induced substance (OASIS) family chemical chaperone PKR-like endoplasmic reticulum kinase (PERK) inositol requirement 1 (IRE1) activating transcription factor 6 (ATF6) endoplasmic reticulum stress
ISSN:	1422-0067, 1661-6596, 1422-0067
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Popis
Shrnutí:	The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms18020382