Endoplasmic Reticulum (ER) Stress and Endocrine Disorders
The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER s...
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| Veröffentlicht in: | International journal of molecular sciences Jg. 18; H. 2; S. 382 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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| ISSN: | 1422-0067, 1661-6596, 1422-0067 |
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| Abstract | The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article. |
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| AbstractList | The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article. The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article.The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the "unfolded protein response" (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related diseases, it has been discovered that endocrine diseases are also related to ER stress. In this review, we focus on ER stress-related human endocrine disorders. In addition to diabetes mellitus, which is well characterized, several relatively rare genetic disorders such as familial neurohypophyseal diabetes insipidus (FNDI), Wolfram syndrome, and isolated growth hormone deficiency type II (IGHD2) are discussed in this article. |
| Author | Hasegawa, Yukihiro Yoshida, Hiderou Ariyasu, Daisuke |
| AuthorAffiliation | 2 Department of Biochemistry and Molecular Biology, Graduate School of Life Science, University of Hyogo, Hyogo 678-1297, Japan 3 Division of Endocrinology and Metabolism, Tokyo Metropolitan Children’s Medical Center, Tokyo 183-8561, Japan 1 Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan; daisukeariyasu@gmail.com |
| AuthorAffiliation_xml | – name: 3 Division of Endocrinology and Metabolism, Tokyo Metropolitan Children’s Medical Center, Tokyo 183-8561, Japan – name: 2 Department of Biochemistry and Molecular Biology, Graduate School of Life Science, University of Hyogo, Hyogo 678-1297, Japan – name: 1 Division of Developmental Genetics, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan; daisukeariyasu@gmail.com |
| Author_xml | – sequence: 1 givenname: Daisuke surname: Ariyasu fullname: Ariyasu, Daisuke – sequence: 2 givenname: Hiderou surname: Yoshida fullname: Yoshida, Hiderou – sequence: 3 givenname: Yukihiro surname: Hasegawa fullname: Hasegawa, Yukihiro |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28208663$$D View this record in MEDLINE/PubMed |
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| Keywords | endocrine disorder old astrocyte specifically induced substance (OASIS) family chemical chaperone PKR-like endoplasmic reticulum kinase (PERK) inositol requirement 1 (IRE1) activating transcription factor 6 (ATF6) endoplasmic reticulum stress |
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| SubjectTerms | Animals Diabetes Disease Models, Animal Endocrine System Diseases - diagnosis Endocrine System Diseases - etiology Endocrine System Diseases - metabolism Endocrine System Diseases - therapy Endoplasmic reticulum Endoplasmic Reticulum Stress Humans Mammals Review Signal Transduction Unfolded Protein Response |
| Title | Endoplasmic Reticulum (ER) Stress and Endocrine Disorders |
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