Cellular and proteomic differences associated with lithium response in olfactory neuroepithelium cells of bipolar disorder patients

Background Lithium is a first-line treatment for bipolar disorder (BD), but only 30% of patients respond satisfactorily to monotherapy, and the biological basis for this variability remains unclear. This study aimed to identify potential biomarkers and therapeutic targets by analyzing olfactory neur...

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Bibliographic Details
Published in:	Molecular medicine (Cambridge, Mass.) Vol. 31; no. 1; pp. 294 - 17
Main Authors:	Hidalgo-Figueroa, Maria, Delgado-Sequera, Alejandra, Pérez-Ramos, Anaid, Durán-Ruiz, MªCarmen, Romero-Lopez-Alberca, Cristina, Pérez-Revuelta, Jose I., Marquez-Estefenn, Ingrid, García-Mompó, Clara, Moreno, Jose Ma Villagrán, Berrocoso, Esther
Format:	Journal Article
Language:	English
Published:	London BioMed Central 26.09.2025 BMC
Subjects:	Adult Biomarkers Biomedical and Life Sciences Biomedicine Bipolar disorder Bipolar Disorder - drug therapy Bipolar Disorder - metabolism Bipolar Disorder - pathology Cell Adhesion - drug effects Cytoskeleton Epithelial Cells - drug effects Epithelial Cells - metabolism Female Humans Lithium Lithium - pharmacology Lithium - therapeutic use Male Middle Aged Molecular Medicine Olfactory Mucosa - drug effects Olfactory Mucosa - metabolism Olfactory Mucosa - pathology Olfactory neuroepithelium Proteome Proteomics Proteomics - methods Bipolar disorder Cytoskeleton Lithium Olfactory neuroepithelium Proteomics
ISSN:	1528-3658, 1528-3658
Online Access:	Get full text
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