Diversity matters: opportunities in the study of the genetics of psychotic disorders in low- and middle-income countries in Latin America

Lack of diversity regarding genetic and environmental backgrounds weakens the generalization and clinical applicability of research findings on psychotic disorders. Notably, Latin Americans have been generally neglected in genetic studies, comprising less than 2% of genome-wide association study sam...

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Vydané v:Revista brasileira de psiquiatria Ročník 43; číslo 6; s. 631 - 637
Hlavní autori: Fonseca, Lais, Sena, Brena F., Crossley, Nicolas, Lopez-Jaramillo, Carlos, Koenen, Karestan, Freimer, Nelson B., Bressan, Rodrigo A., Belangero, Sintia I., Santoro, Marcos L., Gadelha, Ary
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Brazil Associação Brasileira de Psiquiatria 01.11.2021
Associação Brasileira de Psiquiatria (ABP)
Predmet:
Developing Countries
environment
Ethnicity
genetics
Genome-Wide Association Study
Humans
Latin America
Latin America - epidemiology
PSYCHIATRY
psychotic disorders
Psychotic Disorders - genetics
schizophrenia
Special
Latin America
environment
genetics
schizophrenia
psychotic disorders
Latin America
ISSN:1516-4446, 1809-452X, 1809-452X
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Popis
Shrnutí:Lack of diversity regarding genetic and environmental backgrounds weakens the generalization and clinical applicability of research findings on psychotic disorders. Notably, Latin Americans have been generally neglected in genetic studies, comprising less than 2% of genome-wide association study samples. But Latin American populations represent a unique opportunity for research, given the exceptionally high ethnic admixture of this group. Increasing genetic diversity is essential to improve the fine mapping of known regions associated with psychotic disorders, discover novel genetic associations, and replicate studies. Additionally, Latin America is characterized by massive social, political, and economic inequalities, all known risk factors for mental health issues, including psychotic disorders. This article aims to 1) discuss the challenges and advantages of studying Latin America's particular genetic makeup and environmental context; 2) review previous studies conducted in the region; and 3) describe three Latin American research initiatives in progress: the Neuropsychiatric Genetics of Psychosis in Mexican Populations (NeuroMEX), the Paisa, and the Latin American Network for the Study of Early Psychosis (ANDES) studies.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
These authors have contributed equally to this manuscript
ISSN:1516-4446
1809-452X
1809-452X
DOI:10.1590/1516-4446-2020-1240