Topographic organization of the human subcortex unveiled with functional connectivity gradients

Brain atlases are fundamental to understanding the topographic organization of the human brain, yet many contemporary human atlases cover only the cerebral cortex, leaving the subcortex a terra incognita. We use functional MRI (fMRI) to map the complex topographic organization of the human subcortex...

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Veröffentlicht in:Nature neuroscience Jg. 23; H. 11; S. 1421 - 1432
Hauptverfasser: Tian, Ye, Margulies, Daniel S, Breakspear, Michael, Zalesky, Andrew
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Nature Publishing Group 01.11.2020
Schlagworte:
Adult
Amygdala
Atlases as Topic
Brain
Brain - anatomy & histology
Brain - diagnostic imaging
Brain - physiology
Brain architecture
Brain mapping
Cerebral cortex
Cognitive ability
Connectome - methods
Female
Field strength
Functional magnetic resonance imaging
Functionally gradient materials
Humans
Magnetic Resonance Imaging
Male
Neural networks
Neural Pathways - anatomy & histology
Neural Pathways - physiology
Organizational structure
Subdivisions
Topography
Young Adult
ISSN:1097-6256, 1546-1726, 1546-1726
Online-Zugang:Volltext
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Zusammenfassung:Brain atlases are fundamental to understanding the topographic organization of the human brain, yet many contemporary human atlases cover only the cerebral cortex, leaving the subcortex a terra incognita. We use functional MRI (fMRI) to map the complex topographic organization of the human subcortex, revealing large-scale connectivity gradients and new areal boundaries. We unveil four scales of subcortical organization that recapitulate well-known anatomical nuclei at the coarsest scale and delineate 27 new bilateral regions at the finest. Ultrahigh field strength fMRI corroborates and extends this organizational structure, enabling the delineation of finer subdivisions of the hippocampus and the amygdala, while task-evoked fMRI reveals a subtle subcortical reorganization in response to changing cognitive demands. A new subcortical atlas is delineated, personalized to represent individual differences and used to uncover reproducible brain-behavior relationships. Linking cortical networks to subcortical regions recapitulates a task-positive to task-negative axis. This new atlas enables holistic connectome mapping and characterization of cortico-subcortical connectivity.
Bibliographie:ObjectType-Article-1
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ISSN:1097-6256
1546-1726
1546-1726
DOI:10.1038/s41593-020-00711-6