Bilateral entry and release of Middle East respiratory syndrome coronavirus induces profound apoptosis of human bronchial epithelial cells

The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-...

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Bibliographic Details
Published in:Journal of virology Vol. 87; no. 17; p. 9953
Main Authors: Tao, Xinrong, Hill, Terence E, Morimoto, Chikao, Peters, Clarence J, Ksiazek, Thomas G, Tseng, Chien-Te K
Format: Journal Article
Language:English
Published: United States 01.09.2013
Subjects:
Apoptosis
Bronchi - pathology
Bronchi - virology
Cell Line
Cell Polarity
Coronavirus - pathogenicity
Coronavirus - physiology
Cytopathogenic Effect, Viral - physiology
Epithelial Cells - pathology
Epithelial Cells - virology
Humans
SARS Virus - pathogenicity
SARS Virus - physiology
Species Specificity
Virus Internalization
Virus Release - physiology
ISSN:1098-5514, 1098-5514
Online Access:Get more information
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Summary:The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) infects human bronchial epithelial Calu-3 cells. Unlike severe acute respiratory syndrome (SARS)-CoV, which exclusively infects and releases through the apical route, this virus can do so through either side of polarized Calu-3 cells. Infection results in profound apoptosis within 24 h irrespective of its production of titers that are lower than those of SARS-CoV. Together, our results provide new insights into the dissemination and pathogenesis of MERS-CoV and may indicate that the virus differs markedly from SARS-CoV.
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ISSN:1098-5514
1098-5514
DOI:10.1128/JVI.01562-13