KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes. Activation of...

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Veröffentlicht in:	Medicinal research reviews Jg. 43; H. 1; S. 237 - 287
Hauptverfasser:	Crisman, Enrique, Duarte, Pablo, Dauden, Esteban, Cuadrado, Antonio, Rodríguez‐Franco, María Isabel, López, Manuela G., León, Rafael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Wiley Subscription Services, Inc 01.01.2023 John Wiley and Sons Inc
Schlagworte:	chronic diseases Humans Inflammation - drug therapy KEAP1‐NRF2 protein–protein interaction inhibitors Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors Kelch-Like ECH-Associated Protein 1 - metabolism Neurodegenerative Diseases NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - metabolism NRF2 NRF2‐ARE pathway therapeutic potential Oxidative Stress phase II antioxidant response Proteins Review KEAP1-NRF2 protein-protein interaction inhibitors phase II antioxidant response NRF2 NRF2-ARE pathway therapeutic potential chronic diseases
ISSN:	0198-6325, 1098-1128, 1098-1128
Online-Zugang:	Volltext
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