Naturally derived cytokine peptides limit virus replication and severe disease during influenza A virus infection

Objectives Novel host‐targeted therapeutics could treat severe influenza A virus (IAV) infections, with reduced risk of drug resistance. LAT8881 is a synthetic form of the naturally occurring C‐terminal fragment of human growth hormone. Acting independently of the growth hormone receptor, it can red...

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Bibliographic Details
Published in:	Clinical & translational immunology Vol. 12; no. 3; pp. e1443 - n/a
Main Authors:	Harpur, Christopher M, West, Alison C, Le Page, Mélanie A, Lam, Maggie, Hodges, Christopher, Oseghale, Osezua, Gearing, Andrew J, Tate, Michelle D
Format:	Journal Article
Language:	English
Published:	Australia John Wiley & Sons, Inc 2023 John Wiley and Sons Inc Wiley
Subjects:	Alveoli Animal models Antiviral drugs Cell viability Clinical trials Coronaviruses cytokine Cytokines Cytotoxicity Disease resistance Drug resistance Experiments Growth hormones host‐targeted immunotherapy Infections Inflammation Influenza Influenza A influenza virus Macrophages Neuropathy Original Oseltamivir Osteoarthritis Pandemics Peptides Prolactin Proteins pulmonary disease Replication siRNA Viral infections Viruses cytokine host‐targeted immunotherapy influenza virus pulmonary disease
ISSN:	2050-0068, 2050-0068
Online Access:	Get full text
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