Gating of social reward by oxytocin in the ventral tegmental area

The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward circuitry, is necessary to elicit social reward. During social interactions, acti...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 357; H. 6358; S. 1406
Hauptverfasser:	Hung, Lin W, Neuner, Sophie, Polepalli, Jai S, Beier, Kevin T, Wright, Matthew, Walsh, Jessica J, Lewis, Eastman M, Luo, Liqun, Deisseroth, Karl, Dölen, Gül, Malenka, Robert C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 29.09.2017
Schlagworte:	Animals Dopaminergic Neurons - physiology Integrases Interpersonal Relations Mice Mice, Knockout Oxytocin - genetics Oxytocin - secretion Paraventricular Hypothalamic Nucleus - cytology Presynaptic Terminals - physiology Reward Social Behavior Ventral Tegmental Area - secretion
ISSN:	1095-9203, 1095-9203
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Abstract	The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward circuitry, is necessary to elicit social reward. During social interactions, activity in paraventricular nucleus (PVN) OXT neurons increased. Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial behaviors. Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social interactions. OXT increased excitatory drive onto reward-specific VTA dopamine (DA) neurons. These results demonstrate that OXT promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences.
AbstractList	The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward circuitry, is necessary to elicit social reward. During social interactions, activity in paraventricular nucleus (PVN) OXT neurons increased. Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial behaviors. Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social interactions. OXT increased excitatory drive onto reward-specific VTA dopamine (DA) neurons. These results demonstrate that OXT promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences. The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward circuitry, is necessary to elicit social reward. During social interactions, activity in paraventricular nucleus (PVN) OXT neurons increased. Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial behaviors. Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social interactions. OXT increased excitatory drive onto reward-specific VTA dopamine (DA) neurons. These results demonstrate that OXT promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences.The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral tegmental area (VTA), a key node of the brain's reward circuitry, is necessary to elicit social reward. During social interactions, activity in paraventricular nucleus (PVN) OXT neurons increased. Direct activation of these neurons in the PVN or their terminals in the VTA enhanced prosocial behaviors. Conversely, inhibition of PVN OXT axon terminals in the VTA decreased social interactions. OXT increased excitatory drive onto reward-specific VTA dopamine (DA) neurons. These results demonstrate that OXT promotes prosocial behavior through direct effects on VTA DA neurons, thus providing mechanistic insight into how social interactions can generate rewarding experiences.
Author	Lewis, Eastman M Walsh, Jessica J Malenka, Robert C Deisseroth, Karl Luo, Liqun Dölen, Gül Neuner, Sophie Beier, Kevin T Wright, Matthew Hung, Lin W Polepalli, Jai S
Author_xml	– sequence: 1 givenname: Lin W orcidid: 0000-0003-1184-1035 surname: Hung fullname: Hung, Lin W organization: The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia – sequence: 2 givenname: Sophie orcidid: 0000-0002-3465-9706 surname: Neuner fullname: Neuner, Sophie organization: Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA – sequence: 3 givenname: Jai S orcidid: 0000-0003-2004-2163 surname: Polepalli fullname: Polepalli, Jai S organization: Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA – sequence: 4 givenname: Kevin T surname: Beier fullname: Beier, Kevin T organization: Department of Biology, Stanford University, Stanford, CA, USA – sequence: 5 givenname: Matthew orcidid: 0000-0001-7131-7492 surname: Wright fullname: Wright, Matthew organization: Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA – sequence: 6 givenname: Jessica J surname: Walsh fullname: Walsh, Jessica J organization: Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA – sequence: 7 givenname: Eastman M orcidid: 0000-0003-0647-0719 surname: Lewis fullname: Lewis, Eastman M organization: Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA – sequence: 8 givenname: Liqun orcidid: 0000-0001-5467-9264 surname: Luo fullname: Luo, Liqun organization: Department of Biology, Stanford University, Stanford, CA, USA – sequence: 9 givenname: Karl orcidid: 0000-0001-9440-3967 surname: Deisseroth fullname: Deisseroth, Karl organization: Departments of Bioengineering and Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA – sequence: 10 givenname: Gül orcidid: 0000-0003-1780-995X surname: Dölen fullname: Dölen, Gül organization: Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA – sequence: 11 givenname: Robert C orcidid: 0000-0002-5428-5211 surname: Malenka fullname: Malenka, Robert C email: malenka@stanford.edu organization: Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA. malenka@stanford.edu
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28963257$$D View this record in MEDLINE/PubMed
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Snippet	The reward generated by social interactions is critical for promoting prosocial behaviors. Here we present evidence that oxytocin (OXT) release in the ventral...
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SubjectTerms	Animals Dopaminergic Neurons - physiology Integrases Interpersonal Relations Mice Mice, Knockout Oxytocin - genetics Oxytocin - secretion Paraventricular Hypothalamic Nucleus - cytology Presynaptic Terminals - physiology Reward Social Behavior Ventral Tegmental Area - secretion
Title	Gating of social reward by oxytocin in the ventral tegmental area
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