Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, is enriched in circulatory fluids, and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function, and disease. S1PRs regulate es...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 366; číslo 6463
Hlavní autoři:	Cartier, Andreane, Hla, Timothy
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 18.10.2019
Témata:	Animals Apolipoproteins M - metabolism Autoimmune Diseases - drug therapy Autoimmune Diseases - physiopathology Cardiovascular Diseases - drug therapy Cardiovascular Diseases - physiopathology Cardiovascular Physiological Phenomena Cardiovascular System - embryology Cardiovascular System - growth & development Cardiovascular System - metabolism Central Nervous System - growth & development Central Nervous System - physiology Drug Development Fibrosis - drug therapy Fibrosis - physiopathology Homeostasis Humans Immune System Phenomena Lysophospholipids - metabolism Mice Molecular Chaperones Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - physiopathology Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine-1-Phosphate Receptors - antagonists & inhibitors Sphingosine-1-Phosphate Receptors - metabolism
ISSN:	1095-9203, 1095-9203
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