Sphingosine 1-phosphate: Lipid signaling in pathology and therapy

Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, is enriched in circulatory fluids, and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function, and disease. S1PRs regulate es...

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Vydáno v:Science (American Association for the Advancement of Science) Ročník 366; číslo 6463
Hlavní autoři: Cartier, Andreane, Hla, Timothy
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 18.10.2019
Témata:
Animals
Apolipoproteins M - metabolism
Autoimmune Diseases - drug therapy
Autoimmune Diseases - physiopathology
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - physiopathology
Cardiovascular Physiological Phenomena
Cardiovascular System - embryology
Cardiovascular System - growth & development
Cardiovascular System - metabolism
Central Nervous System - growth & development
Central Nervous System - physiology
Drug Development
Fibrosis - drug therapy
Fibrosis - physiopathology
Homeostasis
Humans
Immune System Phenomena
Lysophospholipids - metabolism
Mice
Molecular Chaperones
Neurodegenerative Diseases - drug therapy
Neurodegenerative Diseases - physiopathology
Signal Transduction
Sphingosine - analogs & derivatives
Sphingosine - metabolism
Sphingosine-1-Phosphate Receptors - antagonists & inhibitors
Sphingosine-1-Phosphate Receptors - metabolism
ISSN:1095-9203, 1095-9203
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Shrnutí:Sphingosine 1-phosphate (S1P), a metabolic product of cell membrane sphingolipids, is bound to extracellular chaperones, is enriched in circulatory fluids, and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, postnatal organ function, and disease. S1PRs regulate essential processes such as adaptive immune cell trafficking, vascular development, and homeostasis. Moreover, S1PR signaling is a driver of multiple diseases. The past decade has witnessed an exponential growth in this field, in part because of multidisciplinary research focused on this lipid mediator and the application of S1PR-targeted drugs in clinical medicine. This has revealed fundamental principles of lysophospholipid mediator signaling that not only clarify the complex and wide ranging actions of S1P but also guide the development of therapeutics and translational directions in immunological, cardiovascular, neurological, inflammatory, and fibrotic diseases.
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ISSN:1095-9203
1095-9203
DOI:10.1126/science.aar5551