Stearoyl-CoA desaturase inhibition is toxic to acute myeloid leukemia displaying high levels of the de novo fatty acid biosynthesis and desaturation

Identification of specific and therapeutically actionable vulnerabilities, ideally present across multiple mutational backgrounds, is needed to improve acute myeloid leukemia (AML) patients’ outcomes. We identify stearoyl-CoA desaturase (SCD), the key enzyme in fatty acid (FA) desaturation, as progn...

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Bibliographic Details
Published in:	Leukemia Vol. 38; no. 11; pp. 2395 - 2409
Main Authors:	Dembitz, Vilma, Lawson, Hannah, Burt, Richard, Natani, Sirisha, Philippe, Céline, James, Sophie C., Atkinson, Samantha, Durko, Jozef, Wang, Lydia M., Campos, Joana, Magee, Aoife M. S., Woodley, Keith, Austin, Michael J., Rio-Machin, Ana, Casado, Pedro, Bewicke-Copley, Findlay, Rodriguez Blanco, Giovanny, Pereira-Martins, Diego, Oudejans, Lieve, Boet, Emeline, von Kriegsheim, Alex, Schwaller, Juerg, Finch, Andrew J., Patel, Bela, Sarry, Jean-Emmanuel, Tamburini, Jerome, Schuringa, Jan Jacob, Hazlehurst, Lori, Copland III, John A., Yuneva, Mariia, Peck, Barrie, Cutillas, Pedro, Fitzgibbon, Jude, Rouault-Pierre, Kevin, Kranc, Kamil, Gallipoli, Paolo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.11.2024 Nature Publishing Group Springer Nature
Subjects:	13/106 13/109 13/2 13/31 13/89 38 38/109 38/91 631/67/1990/283/1897 631/67/2327 64/60 692/308/153 82/58 82/80 Acute myeloid leukemia Animals Biobanks Biocompatibility Biology Biomarkers Biosynthesis Cancer Cancer Research Cancer therapies Cell culture Cell death Cell Line, Tumor Chemotherapy Chromatography Critical Care Medicine Damage detection Desaturase Desaturation DNA biosynthesis DNA damage DNA Damage - drug effects Enzyme Inhibitors - pharmacology Enzymes Experiments Fatty acids Fatty Acids - biosynthesis Fatty Acids - metabolism Glucose Hematology Humans Intensive Internal Medicine Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Life Sciences Medical prognosis Medical research Medicine Medicine & Public Health Metabolism Metabolites Mice Oncology Prognosis Stearoyl-CoA desaturase Stearoyl-CoA Desaturase - antagonists & inhibitors Stearoyl-CoA Desaturase - genetics Stearoyl-CoA Desaturase - metabolism Toxicity Xenograft Model Antitumor Assays
ISSN:	0887-6924, 1476-5551, 1476-5551
Online Access:	Get full text
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