Lamotrigine induced priapism in children: case analysis and literature review

Lamotrigine is an antiepileptic drug that can be used to control many types of seizures as a single-agent or an add-on therapy in patients over 2 years of age. In addition to common adverse reactions, this current case report describes a paediatric male patient with a rare side-effect of persistent...

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Vydáno v:Journal of international medical research Ročník 50; číslo 11; s. 3000605221133988
Hlavní autoři: Ge, Jie, Cao, Shan-Shan, Cao, Xiao-Yu, Tang, Meng, Mu, Fei, Qiao, Yi, Guan, Yue, Wang, Jing-Wen
Médium: Journal Article
Jazyk:angličtina
Vydáno: London, England SAGE Publications 01.11.2022
Sage Publications Ltd
SAGE Publishing
Témata:
Anticonvulsants
Case Reports
Children & youth
Epilepsy
Genital diseases
Penis
Side effects
case report
children
Lamotrigine
priapism
ISSN:0300-0605, 1473-2300, 1473-2300
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Shrnutí:Lamotrigine is an antiepileptic drug that can be used to control many types of seizures as a single-agent or an add-on therapy in patients over 2 years of age. In addition to common adverse reactions, this current case report describes a paediatric male patient with a rare side-effect of persistent penile erectile due to lamotrigine. Previous studies have shown that it can improve sexual function in adult male patients. This patient suffered from refractory epilepsy and pneumonia. He had taken a variety of antiepileptic drugs for a long time and developed priapism after the dosage of lamotrigine had been increased. The priapism improved after drug withdrawal and sedation. Further research is needed to elucidate the mechanism of this rare side-effect.
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ISSN:0300-0605
1473-2300
1473-2300
DOI:10.1177/03000605221133988