Evolutionary plasticity of segmentation clock networks

The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythm...

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Published in:	Development (Cambridge) Vol. 138; no. 13; p. 2783
Main Authors:	Krol, Aurélie J, Roellig, Daniela, Dequéant, Mary-Lee, Tassy, Olivier, Glynn, Earl, Hattem, Gaye, Mushegian, Arcady, Oates, Andrew C, Pourquié, Olivier
Format:	Journal Article
Language:	English
Published:	England 01.07.2011
Subjects:	Animals Biological Clocks - genetics Biological Clocks - physiology Chickens Evolution, Molecular Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism In Situ Hybridization Mice Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction - genetics Signal Transduction - physiology Wnt Proteins - genetics Wnt Proteins - metabolism Zebrafish
ISSN:	1477-9129, 1477-9129
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Abstract	The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.
AbstractList	The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks. The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.
Author	Pourquié, Olivier Dequéant, Mary-Lee Hattem, Gaye Mushegian, Arcady Tassy, Olivier Oates, Andrew C Glynn, Earl Krol, Aurélie J Roellig, Daniela
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Snippet	The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is...
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SubjectTerms	Animals Biological Clocks - genetics Biological Clocks - physiology Chickens Evolution, Molecular Fibroblast Growth Factors - genetics Fibroblast Growth Factors - metabolism In Situ Hybridization Mice Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Receptors, Notch - genetics Receptors, Notch - metabolism Signal Transduction - genetics Signal Transduction - physiology Wnt Proteins - genetics Wnt Proteins - metabolism Zebrafish
Title	Evolutionary plasticity of segmentation clock networks
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