Evolutionary plasticity of segmentation clock networks

The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythm...

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Bibliographic Details
Published in:Development (Cambridge) Vol. 138; no. 13; p. 2783
Main Authors: Krol, Aurélie J, Roellig, Daniela, Dequéant, Mary-Lee, Tassy, Olivier, Glynn, Earl, Hattem, Gaye, Mushegian, Arcady, Oates, Andrew C, Pourquié, Olivier
Format: Journal Article
Language:English
Published: England 01.07.2011
Subjects:
Animals
Biological Clocks - genetics
Biological Clocks - physiology
Chickens
Evolution, Molecular
Fibroblast Growth Factors - genetics
Fibroblast Growth Factors - metabolism
In Situ Hybridization
Mice
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Receptors, Notch - genetics
Receptors, Notch - metabolism
Signal Transduction - genetics
Signal Transduction - physiology
Wnt Proteins - genetics
Wnt Proteins - metabolism
Zebrafish
ISSN:1477-9129, 1477-9129
Online Access:Get more information
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Summary:The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.
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ISSN:1477-9129
1477-9129
DOI:10.1242/dev.063834