Posttranscriptional Gene Regulation by Long Noncoding RNA

Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs...

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Veröffentlicht in:Journal of molecular biology Jg. 425; H. 19; S. 3723 - 3730
Hauptverfasser: Yoon, Je-Hyun, Abdelmohsen, Kotb, Gorospe, Myriam
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier Ltd 09.10.2013
Schlagworte:
Cell Line, Tumor
eukaryotic cells
gene expression
genes
genetics
human diseases
Humans
lincRNA
lncRNA
messenger RNA
metabolism
microRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
mRNA turnover
non-coding RNA
RNA precursors
RNA Processing, Post-Transcriptional
RNA Splicing
RNA Stability
RNA, Long Noncoding
RNA, Messenger
RNA, Messenger - genetics
RNA, Messenger - metabolism
RNA-binding protein
RNA-binding proteins
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
transcription (genetics)
translation (genetics)
translational regulation
BACE1
pre-mRNA
RNA-binding protein
lncRNA
sno-lncRNA
mRNA turnover
lincRNA
PABP
translational regulation
poly(A)-binding protein
β amyloid-cleaving enzyme 1
precursor mRNA
small nucleolar lncRNA
long noncoding RNA
ISSN:0022-2836, 1089-8638, 1089-8638
Online-Zugang:Volltext
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Zusammenfassung:Eukaryotic cells transcribe a vast number of noncoding RNA species. Among them, long noncoding RNAs (lncRNAs) have been widely implicated in the regulation of gene transcription. However, examples of posttranscriptional gene regulation by lncRNAs are emerging. Through extended base-pairing, lncRNAs can stabilize or promote the translation of target mRNAs, while partial base-pairing facilitates mRNA decay or inhibits target mRNA translation. In the absence of complementarity, lncRNAs can suppress precursor mRNA splicing and translation by acting as decoys of RNA-binding proteins or microRNAs and can compete for microRNA-mediated inhibition leading to increased expression of the mRNA. Through these regulatory mechanisms, lncRNAs can elicit differentiation, proliferation, and cytoprotective programs, underscoring the rising recognition of lncRNA roles in human disease. In this review, we summarize the mechanisms of posttranscriptional gene regulation by lncRNAs identified until now. [Display omitted] ► LncRNAs are emerging as key posttranscriptional gene regulatory factors. ► LncRNAs can control splicing by sequestering splicing regulatory proteins. ► LncRNAs can modulate target mRNA turnover via partial or extended complementarity. ► LncRNAs can affect translation by interacting with target mRNAs, recruiting proteins. ► LncRNAs can function by competing or cooperating with microRNAs.
Bibliographie:http://dx.doi.org/10.1016/j.jmb.2012.11.024
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0022-2836
1089-8638
1089-8638
DOI:10.1016/j.jmb.2012.11.024