Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease

ABSTRACT Background Neurofilament light chain protein (NfL) is a promising biomarker of neurodegeneration. Objectives To determine whether plasma and CSF NfL (1) associate with motor or cognitive status in Parkinson's disease (PD) and (2) predict future motor or cognitive decline in PD. Methods...

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Bibliographic Details
Published in:	Movement disorders Vol. 36; no. 12; pp. 2945 - 2950
Main Authors:	Aamodt, Whitley W., Waligorska, Teresa, Shen, Junchao, Tropea, Thomas F., Siderowf, Andrew, Weintraub, Daniel, Grossman, Murray, Irwin, David, Wolk, David A., Xie, Sharon X., Trojanowski, John Q., Shaw, Leslie M., Chen‐Plotkin, Alice S.
Format:	Journal Article
Language:	English
Published:	Hoboken, USA John Wiley & Sons, Inc 01.12.2021 Wiley Subscription Services, Inc
Subjects:	Biomarkers Biomarkers - cerebrospinal fluid Cerebrospinal fluid Cognition Cognitive ability Cognitive Dysfunction - cerebrospinal fluid Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Cross-Sectional Studies Dementia Dementia disorders Disease Progression Humans Intermediate Filaments - metabolism Medical prognosis Movement disorders Neurodegeneration Neurodegenerative diseases neurofilament light chain protein NfL Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson's disease Plasma prognosis Regression analysis Parkinson's disease neurofilament light chain protein NfL prognosis biomarkers
ISSN:	0885-3185, 1531-8257, 1531-8257
Online Access:	Get full text
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